We propose an experimental scheme to realize the valley-dependent gauge fields for ultracold fermionic atoms trapped in a state-dependent square optical lattice. Our scheme relies on two sets of Raman laser beams to engineer the hopping between adjacent sites populated by two-component fermionic atoms. One set of Raman beams are used to realize a staggered π-flux lattice, where low energy atoms near two inequivalent Dirac points should be described by the Dirac equation for spin-1/2 particles. Another set of laser beams with proper Rabi frequencies are added to further modulate the atomic hopping parameters. The hopping modulation will give rise to effective gauge potentials with opposite signs near the two valleys, mimicking the interesting strain-induced pseudogauge fields in graphene. The proposed valley-dependent gauge fields are tunable and provide a new route to realize quantum valley Hall effects and atomic valleytronics. The low-energy effective theory of graphene describes relativistic Dirac fermions near the two inequivalent corners of the Brillouin zone, termed valleys [1]. Valley index plays an important role in the extraordinary electronic properties of graphene. Valley-dependent gauge fields, usually called pseudo-gauge fields to distinguish from the real valley-independent electromagnetic field in unstrained graphene, have recently been studied extensively both theoretically [2-4] and experimentally [5,6]. It has been show that such gauge fields can be realized by modulating the electronic hopping with strains in a two-dimensional (2D) honeycomb lattice [5,6]. These findings open up an exciting area of mechanically engineering band structure of graphene [3], as well as realizing some exotic phenomena absent in other solid-state materials, such as new types of quantum Hall related effects [4,7].On the other hand, a growing class of Dirac materials with synthetic honeycomb structure have recently been proposed and explored [8], such as trapped cold atoms in optical lattices (OL) [9,10], confined photons in photonic crystals [11,12], and molecular graphene [13]. Interestingly, the pseudo-magnetic fields and related Landau levels have been experimentally demonstrated in photonic graphene [11] and molecular graphene [13] by designing a spatial texture of hopping parameters. In addition, the creation and manipulation of Dirac points with a Fermi gas in a honeycomb OL have been also reported recently [10]. A promising extension in this cold atom system is to simulate the tunable valley-dependent gauge fields and realize the related novel effects. For this purpose, a practical way is to modulate the atomic hopping parameters in a honeycomb OL by using the synthetic gauge poten- * Electronic address: slzhunju@163.com tials [14] or the laser-assisted tunneling (LAT) [15,16], following the schemes proposed in Refs. [17][18][19]. However, the LAT technique has not yet been demonstrated in honeycomb OLs, but in square optical (super) lattices [20][21][22]. Therefore, a natural question is whether one can simul...