In this paper, employing the uniform modified form of the generalized offshell Helmholtz free energy, we investigate the topological numbers for the whole class of four-dimensional NUT-charged spacetimes. We find that, while the topological numbers of almost all four-dimensional NUT-charged spacetimes (except the Taub-NUT spacetime and Kerr-NUT spacetime) vary depending on the values of the solution parameters, the entire class of four-dimensional NUT-charged spacetime solutions can still be classified as one of the three types of well-known black hole solutions. Thus, the whole class of four-dimensional NUT-charged spacetimes should be viewed as generic black holes from the viewpoint of the thermodynamic topological approach. Furthermore, the fourdimensional Reissner-Nordström-Taub-NUT (RN-NUT) spacetime, Kerr-Newman-NUT (KN-NUT) spacetime, and RN-NUT-AdS spacetime provide three counterexamples that are in sharp contrast to the conclusions reached in all previous works, which conclude that a black hole solution only has one certain topological number, independent of the values of the solution parameters. What is more, these topological numbers could help us unravel the mysteries of NUT-charged spacetimes with their so many peculiar properties and shed new light on the research of black hole thermodynamics.