Toralactone glycoside in Cassia obtusifolia mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism

Seo, Yongtaek; Song, Jae-Sook; Kim, Youngmi; Jang, Young Pyo

doi:10.1016/j.foodres.2017.04.032

Cited by 15 publications

(10 citation statements)

References 33 publications

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“…Accordingly, their laxative effects and underlying mechanisms on constipation have been intensively studied [ 29 ]. CO and FV have the beneficial effects against many diseases, including hepatoprotection [ 30 , 31 ], neuroprotection [ 32 ], and antioxidant [ 33 ] [ 34 ]. CO exhibited the preventive effect against hyperlipidemia by decreasing serum low-density lipoprotein and triglycerides [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats

Jang¹,

Yang

2018

PLoS ONE

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Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life. Cassia obtusifolia L. (CO) and Foeniculum vulgare M. (FV) are commonly used as medicinal foods in many countries. We aimed to examine the laxative effect and their underlying mechanism of CO and FV mixture on loperamide (lop)-induced constipated rats. To determine the laxative effects of these compounds, Sprague-Dawley rats were divided into six groups: the control, lop-induced constipated (2mg/kg), and three doses (100, 300, and 500mg/kg) of CO and FV mixture-, and Bisacodyl (bis, 3.3mg/kg)-treated groups. The mixture of CO and FV and bis were orally administered once a day for 4 weeks. For induction of constipation, the lop were treated with a dose of 2 mg/kg twice a day on the 3rd week after treatments of CO and FV extracts and bis. The results were revealed that the CO and FV mixture has the laxative effects more than those in CO and FV-alone treatments on constipated rats by determining the stool parameters, including stool number and weight. Indeed, stool parameters, such as, stool number, weight, and water contents and colonic peristalsis from the intestinal transit length and ratio were dramatically improved by CO and FV mixture treatment. Histological study also revealed that CO and FV mixture enhanced the thicknesses of mucosa and muscular layers of the colon in constipated rats. For their underlying mechanism, the mRNAs and proteins expression of muscarinic acetylcholine receptors (mAchR) M2 and M3 and their downstream signaling were preserved by CO and FV mixture treatment in constipated rats. Therefore, this study suggests that treatment with CO and FV mixture has beneficial effects against constipation. We further suggest that CO and FV mixture may be utilized as an alternative therapeutic strategy for constipation.

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Section: Discussionmentioning

confidence: 99%

The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats

Jang¹,

Yang

2018

PLoS ONE

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“…Cassia glycosides can protect against tert -butylhydroperoxide induced cell death in HepG2 cells, and this hepatoprotective effects were exerted through nuclear factor erythroid-2-related factor 2 (Nrf2)-dependent antioxidative signaling [ 110 , 111 ]. In high fat and high sugar model of NAFLD, cassia glycosides can obviously improve liver function and regulate blood lipids when compared with the commonly used drug polyene phosphatidylcholine in clinic, which is related with the inhibition of SREBP-1c expression in liver [ 112 ].…”

Section: Effects and Mechanisms Of Commonly Used Single Herb Drugs In Tcm On Nafldmentioning

confidence: 99%

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

et al. 2021

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Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM’s holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease. However, the multi-compounds and multi-targets are big obstacle for the study of TCM. Here, we summarize the pharmacological actions of active ingredients from frequently used single herbs in TCM compounds. The combined mechanism of herbs in TCM compounds are further discussed to explore their comprehensive effects on NAFLD. This article aims to summarize multiple functions and find the common ground for TCM treatment on NAFLD, thus providing enrichment to the scientific connotation of TCM theories and promotes the exploration of TCM therapies on NAFLD.

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“…Cassiaside, a naphthopyrone glucoside and a major constituent of C . obtusifolia , has previously been reported to have a wide range of biological activities including anti‐diabetic (Jung et al, ; Jung, Ali, & Choi, ; Lee, Jang, Lee, Kim, & Kim, ), antimutagenic (Choi et al, ), antioxidant (Choi et al, ), antimicrobial (Messana, Ferrari, Cavalcanti, & Morace, ), hepatoprotective (Seo et al, ; Wong et al, ), antiallergic (Zhang & Yu, ), anti‐Alzheimer disease (Jung, Ali, Jung, et al, ), and antihypertensive activities (Hyun et al, ). In addition, aloe emodin is an anthraquinones compound that exhibited several biological activities including antibacterial (Coopoosamy & Magwa, ), anticancer (Pecere et al, ), anti‐Alzheimer disease (Jung, Ali, Jung, et al, ), anti‐diabetic (Jung, Ali, & Choi, ), antiviral (Li et al, ), anti‐proliferative (Lin & Uen, ), and anti‐inflammatory activities (Park, Kwon, & Sung, ).…”

Section: Discussionmentioning

confidence: 99%

“…Hepatoprotective effects of different Cassia species have also been investigated in several studies in which Cassia leaf extracts showed hepatoprotective activity against paracetamol, ethyl alcohol, and diethylnitrosamine (Bhakta et al, ; Jafri, Jalis‐Subhani, Javed, & Singh, ; Pradeep, Mohan, Gobianand, & Karthikeyan, ). Recently, Seo, Song, Kim, and Jang () reported the hepatoprotective effects of Cassia seed ethanol extract and its components toralactone glycoside in t ‐BHP‐induced cells death in HepG2 cells. Xie, Guo, and Zhou () reported the protective effects of Cassia seed ethanol extract against carbon tetrachloride (CCl 4 )‐induced liver injury in mice.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of Cassia obtusifolia seed extract and constituents against oxidative damage induced by tert -butyl hydroperoxide in human hepatic HepG2 cells

et al. 2017

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The aim of the present study was to investigate the hepatoprotective effects of different soluble fractions of methanolic derived Cassia obtusifolia seeds extract (COE) and its active components in Overall, COE displayed a significant cytoprotective effect against oxidative stress, which may most likely be because of active compounds like cassiaside, alaternin, and aloe emodin in COE, which leads to maintenance of the normal redox status of cells. Practical applicationsThe dried and roasted seeds of Cassia obtusifolia are commonly consumed as brew tea and medicinal foods in Korea. The seeds have multiple therapeutic actions related to the treatment of liver disease, dementia, diabetes, eye inflammation, photophobia and lacrimation, dysentery, headache, as well as dizziness. The present study demonstrates the hepatoprotective effect through prevention of oxidative stress, suggesting that C. obtusifolia and its constituents may have beneficial effects in preventing hepatic diseases. K E Y W O R D Salaternin, Cassia obtusifolia, cassiaside, hepatoprotection, oxidative stress, t-BHP

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Toralactone glycoside in Cassia obtusifolia mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism

Cited by 15 publications

References 33 publications

The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats

The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

Hepatoprotective effect of Cassia obtusifolia seed extract and constituents against oxidative damage induced by tert -butyl hydroperoxide in human hepatic HepG2 cells

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