Tormentillae rhizoma – Review for an Underestimated European Herbal Drug

Melzig, Matthias F.; Böttger, Stefan

doi:10.1055/a-1129-7214

Cited by 12 publications

(8 citation statements)

References 36 publications

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“…Chemical composition. Hydrolysable tannins (pedunculagin, pentadigalloylglucose, agrimoniin, laevigatin B, tormentillin); condensed tannins/proanthocyanidins ([4,6]-all-trans-bi-(+)-catechin = procyanidin B6, [4,8]-2,3-trans-3,4-cis-bi-(+)-catechin, [4,8]-all-trans-bi-(+)-catechin = procyanidin B3), [6′,6]-all-trans-bi-(+)-catechin, procyanidin B1, procyanidin B2, procyanidin B5, (+)-catechin-[4,8]-(+)-catechin-[4,8]-(+)-catechin, (+)-catechin-[6′,8]-(+)-catechin-[4,8]-(+)-catechin; triterpenoids: 2α,3β-dihydroxyurs-12 -en-28-oic acid β-D-glucopyranosyl ester, 3-epi-pomolic acid 28- O -β-D-glucoside, 3β,19α-dihydroxyolean-12-en-28-oic acid β-D-glucopyranosyl ester, 3β,19α-dihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester, arjunetin, chinovic acid, kaji-ichogoside F1, tormentic acid, tormentoside ( Tomczyk and Latté, 2009 ; Melzig and Böttger, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…Although the clinical evidence is Low, this herbal medicine is considered presenting High safety. (Tomczyk and Latte, 2009;Melzig and Böttger, 2020).…”

Section: Polypodium Vulgare L -Polypodiaceae (Rhizomes)mentioning

confidence: 99%

“…Special warnings and precautions of use. Due to thrombolytic activity (Melzig and Böttger, 2020), caution should be taken to avoid interaction with thrombolytic drugs. Therefore, safety is Medium.…”

Section: Polypodium Vulgare L -Polypodiaceae (Rhizomes)mentioning

confidence: 99%

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COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method: The plant selection was primarily based on species listed by the WHO and EMA, but some other herbal remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical data on their efficacy and safety were collected from authoritative sources. The target population were adults with early and mild flu symptoms without underlying conditions. These were evaluated according to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The benefits/risks balance of the treatments was classified as positive, promising, negative, and unknown. Results: A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases (Allium sativum, Andrographis paniculata, Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulus essential oil, Justicia pectoralis, Magnolia officinalis, Mikania glomerata, Pelargonium sidoides, Pimpinella anisum, Salix sp, Zingiber officinale), and unknown for the rest. On the same grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. Conclusions: Our work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical

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Section: Resultsmentioning

confidence: 99%

“…Although the clinical evidence is Low, this herbal medicine is considered presenting High safety. (Tomczyk and Latte, 2009;Melzig and Böttger, 2020).…”

Section: Polypodium Vulgare L -Polypodiaceae (Rhizomes)mentioning

confidence: 99%

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COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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“…The genus Potentilla L (Rosaceae family) consists of approximately 700 species of annual and biennial plants and small shrubs. Extract from the underground parts of Potentilla erecta (L.) Raeusch (tormentil extract [TE]) has been used in traditional ethnomedicine for the treatment of diarrhea and mild inflammation of the oral mucosa because of its antioxidant and anti-inflammatory activity (Tomczyk and Latté, 2009;Melzig and Böttger, 2020;Augustynowicz et al, 2021). The pharmacological properties of tormentil have been discussed in several reviews and it's monographs are included in the Russian Pharmacopoeia (14th edition), State Pharmacopoeia of the Republic of Belarus, ESCOP, in the British Pharmacopoeia, or the European Pharmacopoeia (10th edition) (Shikov et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes

Marcińczyk

Golaszewska

Gromotowicz-Popławska

et al. 2021

Front. Pharmacol.

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In our previous study, we showed that ellagitannin- and procyanidin-rich tormentil extract (TE) decreased experimental arterial thrombosis in normoglycemic rats through platelet inhibition. TE also slightly increased coagulation and attenuated fibrinolysis; however, these effects did not nullify the antithrombotic effect of TE. The present study aimed to assess whether TE exerts antithrombotic activity in streptozotocin (STZ)-induced diabetes, which is characterized by pre-existing increased coagulation and impaired fibrinolysis, in vivo and ex vivo thrombosis assays. TE (100, 200, or 400 mg/kg, p. o.) was administered for 14 days to STZ-induced diabetic rats and mice. TE at 100 mg/kg dose decreased the thrombus area in the mice model of laser-induced thrombosis through its potent antiplatelet effect. However, TE at 200 mg/kg dose increased thrombus weight in electrically induced arterial thrombosis in rats. The prothrombotic effect could be due to increased coagulation and attenuated fibrinolysis. TE at 400 mg/kg dose also improved vascular functions, which was mainly reflected as an increase in the arterial blood flow, bleeding time prolongation, and thickening of the arterial wall. However, TE at 400 mg/kg dose did not exert antithrombotic effect. Summarizing, the present results show that TE may exert multidirectional effects on hemostasis in STZ-induced diabetic rats and mice. TE inhibited platelet activity and improved endothelial functions, but it also showed unfavorable effects by increasing the activity of the coagulation system and by inhibiting fibrinolysis. These contrasting effects could be the reason for model-specific influence of TE on the thrombotic process in STZ-induced diabetes.

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“…Studies on in vitro models have shown the astringent, antimicrobial, antioxidant, and anti-inflammatory effects of tormentil rhizomes [ 101 ].…”

Section: Phytotherapy In Skin Diseasesmentioning

confidence: 99%

Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota

Melnyk

Vlasova

Skowrońska

et al. 2022

IJMS

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Skin disorders of different etiology, such as dermatitis, atopic dermatitis, eczema, psoriasis, wounds, burns, and others, are widely spread in the population. In severe cases, they require the topical application of drugs, such as antibiotics, steroids, and calcineurin inhibitors. With milder symptoms, which do not require acute pharmacological interventions, medications, dietary supplements, and cosmetic products of plant material origin are gaining greater popularity among professionals and patients. They are applied in various pharmaceutical forms, such as raw infusions, tinctures, creams, and ointments. Although plant-based formulations have been used by humankind since ancient times, it is often unclear what the mechanisms of the observed beneficial effects are. Recent advances in the contribution of the skin microbiota in maintaining skin homeostasis can shed new light on understanding the activity of topically applied plant-based products. Although the influence of various plants on skin-related ailments are well documented in vivo and in vitro, little is known about the interaction with the network of the skin microbial ecosystem. The review aims to summarize the hitherto scientific data on plant-based topical preparations used in Poland and Ukraine and indicate future directions of the studies respecting recent developments in understanding the etiology of skin diseases. The current knowledge on investigations of interactions of plant materials/extracts with skin microbiome was reviewed for the first time.

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Tormentillae rhizoma – Review for an Underestimated European Herbal Drug

Cited by 12 publications

References 36 publications

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes

Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota

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