SiDMACIB (Structurally informed Design of Masonry Assemblages Composed of Interlocking Blocks) is the first numerical model capable of extending the equilibrium problem of limit analysis to interlocking assemblies. Adopting the concave formulation, this model can compute the stress state at the corrugated faces with orthotropic behaviour, such as their combined torsion-shear capacity. Generally speaking, finding the plastic torsion-shear capacity of planar faces shared between conventional blocks is still a fresh topic, while investigating this capacity for interlocking interfaces is particularly rather unexplored. Upon the authors’ previous works that focused on interlocking blocks with a single lock, in this paper, an extension to blocks composed of several locks (multi-lock interfaces) is presented and the SiDMACIB model is upgraded accordingly. For this purpose, the shear-torsion results obtained from the original SiDMACIB formulation are validated and subsequently compared with those derived from distinct element analysis conducted using the 3DEC 7.0 software. Based on this comparison, revisions to the SiDMACIB model are proposed, involving a reduction in the number of locks affecting torsion-shear capacity.