“…Axially chiral compounds have played an essential role as chiral ligands and catalysts in asymmetric synthesis. , This class of molecules is widely found in numerous pharmaceutical agents and natural products . Out of different axially chiral structures, substituted biaryls ( A and B , Scheme a) have been extensively developed and applied. − More recently, other atropisomers including alkenes and aryl amides ( C and D , Scheme a) have also been under active investigation. − However, these studies mainly focused on the preparation of atropisomers with a single stereogenic axis. Methods to assemble axially chiral molecules with more than one stereogenic axis ( E and F , Scheme a) have rarely been reported, owing to the formidable challenges involved in the assembly of multiple stereogenic axes with high enantiocontrol.…”