Tortoise-shell glue ameliorates male infertility through the hypothalamic-pituitary-gonadal axis in obese rats

Sheng, Wen; Li, Yingqiu; Liu, Lumei; Li, Bonan; Sun, Tiansong; Zhu, Congxu; He, Qinghu

doi:10.1080/19768354.2024.2329684

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Ca 2+ Signaling and Male Contraception1

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2024

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“…Ahn et al 2022 Sheng et al 2024 Long et al 2021 Nieschlag 2010 Wang and Swerdloff 2022 Behre et al 2016 …”

Section: Ca 2+ Signaling and Male Contraceptionunclassified

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system

Lee,

Hwang

2024

Animal Cells and Systems

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Ca 2+ is a key secondary messenger that determines sperm motility patterns. Mammalian sperm undergo capacitation, a process to acquire fertilizing ability, in the female reproductive tract. Capacitated sperm change their flagellar waveform to develop hyperactivated motility, which is crucial for successful sperm navigation to the eggs and fertilization. The sperm-specific channel, CATSPER, and an ATPase transporter, PMCA4, serve as major paths for Ca 2+ influx and efflux, respectively, in sperm. The ionic paths coordinate Ca 2+ homeostasis in the sperm, and their loss-of-function impairs sperm motility, to cause male infertility. In this review, we summarize the physiological significance of these two Ca 2+ gates and suggest their potential applications in novel male contraceptives.

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“…Ahn et al 2022 Sheng et al 2024 Long et al 2021 Nieschlag 2010 Wang and Swerdloff 2022 Behre et al 2016 …”

Section: Ca 2+ Signaling and Male Contraceptionunclassified

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system

Lee,

Hwang

2024

Animal Cells and Systems

View full text Add to dashboard Cite

show abstract

Tortoise-shell glue ameliorates male infertility through the hypothalamic-pituitary-gonadal axis in obese rats

Cited by 1 publication

References 45 publications

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system

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Tortoise-shell glue ameliorates male infertility through the hypothalamic-pituitary-gonadal axis in obese rats

Cited by 1 publication

References 45 publications

Ca 2+ homeostasis and male fertility: a target for a new male contraceptive system

Ca 2+ homeostasis and male fertility: a target for a new male contraceptive system

Contact Info

Product

Resources

About

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system