Tos crónica. Síndrome de hipersensibilidad del reflejo  de la tos

Sacre-Hazouri, José Antonio; Sacre, Lauralicia

doi:10.29262/ram.v66i2.565

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…Cough reflex hypersensitivity is observed in all respiratory diseases (acute or chronic) when cough is a predominant feature. At the same time, neuroinflammation is one of the most important causes of cough reflex hypersensitivity (17). Cranial nerves, including the vagus nerve, may be affected by inflammatory neuropathic processes.…”

Section: Vagal Neuropathymentioning

confidence: 99%

Cough as a neurological sign: Does it worth it?

Al‐Biltagi¹,

Bediwy²,

Saeed³

2021

Preprint

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Cough is one of the most common complaints that lead patients to see a doctor. It is not only a basic respiratory sign but also an important neurological sign. There are 3 main types of cough: reflex cough (type I), voluntary cough (type II), and evoked cough (type III). Reflex cough sensitivity may be increased in many neurological disorders, such as space-occupying lesion of the brainstem, medullary lesions secondary to type I Chiari malformations, tics disorders such as Tourette’s syndrome, somatic cough, neurodegenerative disorders of the cerebellum, and chronic vagal neuropathy due to allergic and nonallergic diseases. On the other hand, cough sensitivity decreases in the cerebral hypoxia, cerebral hemispheric stroke with a brainstem shock, dementia due to Lewy body disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and peripheral neuropathy such as hereditary sensory and autonomic neuropathy type IV, diabetic neuropathy, vitamin B12, and folate deficiency. The ear-cough reflex of Arnold’s nerve, syncopal cough, cough headache, opioid associated cough and cough-anal reflex are signs that can help in the diagnosis of underlying neurological disorders. The cough reflex test is a quick, easy, and inexpensive test that can be performed during the cranial nerve exam. In this article, we have discussed cough reflex testing and various neurological disorders that increase or decrease cough sensitivity.

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Section: Vagal Neuropathymentioning

confidence: 99%

Cough as a neurological sign: Does it worth it?

Al‐Biltagi¹,

Bediwy²,

Saeed³

2021

Preprint

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Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy

et al. 2023

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Background Despite being a new entity, there is a large amount of information on the characteristics of SARS-CoV-2 infection and the symptoms of the acute phase; however, there are still many unknowns about the clinical features and pathophysiology of post-COVID syndrome. Refractory chronic cough is one of the most prevalent symptoms and carries both a medical problem and a social stigma. Many recent studies have highlighted the role of SARS-CoV-2 neurotropism, but no studies have demonstrated vagus nerve neuropathy as a cause of persistent chronic cough or other COVID-19 long-term effects. Objective The main objective was to assess the involvement of the vagus nerve neuropathy as a cause of chronic cough and other post-COVID syndrome symptoms. Material and methods This was a single-center observational study with prospective clinical data collected from 38 patients with chronic cough and post-COVID-19 syndrome. Clinical characteristics and laryngeal electromyographic findings were analyzed. Results Clinical data from 38 patients with chronic cough after 12 weeks of the acute phase of COVID-19 infection were analyzed. Of these patients, 81.6% suffered from other post-COVID conditions and, 73.6% reported fluctuating evolution of symptoms. Laryngeal electromyography (LEMG) of the thyroarytenoid (TA) muscles and cricothyroid (CT) muscles was pathological in 76.3% of the patients. Of the patients with abnormal LEMG, chronic denervation was the most frequent finding (82.8%), 10.3% presented acute denervation signs, and 6.9% presented myopathic pattern in LEMG. Conclusions LEMG studies suggest the existence of postviral vagus nerve neuropathy after SARS-CoV-2 infection that could explain chronic cough in post-COVID syndrome.

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“Perplexing” cough

Ponomareva,

Glotov,

Uryasev

et al. 2024

Pulʹmonologiâ (Mosk.)

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Cough is a serious problem of practical pulmonology. The mechanisms of cough occurrence are diverse and numerous diseases are associated with chronic cough syndrome. The diagnosis can be challenging because of a “perplexing”, “unexplained”, or “idiopathic” cough. The aim of the review was to consider the main underlying mechanisms of the “perplexing” cough, its potential course, an algorithm for managing patients with the persistent cough, and new treatment methods. Conclusion. Chronic “perplexing” cough disrupts the patient’s quality of life and reduces their performance. Unveiling the mechanisms of its development may increase the treatment efficacy.

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Tos crónica. Síndrome de hipersensibilidad del reflejo de la tos

Cited by 4 publications

References 65 publications

Cough as a neurological sign: Does it worth it?

Cough as a neurological sign: Does it worth it?

Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy

“Perplexing” cough

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