Toshio Fujita, 1929–2017

Nakagawa, Yoshiaki; Miyagawa, Hisashi

doi:10.1584/jpestics.m17-01

J. Pestic. Sci.

2017

DOI: 10.1584/jpestics.m17-01

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Toshio Fujita, 1929–2017

Yoshiaki Nakagawa

Hisashi Miyagawa

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How medicinal chemists learned about log P

Martin

2018

J Comput Aided Mol Des

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Although log P is now recognized to be a key factor that determines the bioactivity of a molecule, the focus of medicinal chemists on hydrophobicity and log P started with the quantitative structure-activity relationships (QSAR) publications of Hansch and Fujita. Their original publication represents a dramatic change of focus to incorporate consideration of log P after a decade of work unsuccessfully attempting to use the Hammett equation to explain the structure-activity relationships of plant growth regulators. QSAR allows one to explore the quantitative relationship between log P and biological activity even when other factors also influence potency. In particular, Hansch's publications of thousands of QSAR equations demonstrate that a relationship of biological activity with log P is indeed a general phenomenon. Hansch's group also provided data and tools that enable others to explore the relationship between log P and the biological activity of compounds of interest.

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How medicinal chemists learned about log P

Martin

2018

J Comput Aided Mol Des

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Toshio Fujita, 1929–2017

Cited by 1 publication

References 4 publications

How medicinal chemists learned about log P

How medicinal chemists learned about log P

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