Total and metallothionein-bound cadmium in the liver and the kidney of a population in Barcelona (Spain)

Torra, M.; To‐Figueras, Jordi; Brunet, Mercè; Rodamilans, M.; Corbella, J.

doi:10.1007/bf00199019

Cited by 18 publications

(13 citation statements)

References 19 publications

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“…Kidneys are the major organs from which Cd is excreted from an organism (Goyer et al 1995). The ability of kidneys to accumulate higher amounts of Cd than liver is common to fishes (Hogstrand and Haux 1991), amphibians (Suzuki and Kawamura 1984) and mammals (Torra et al 1994;Massanyi et al 1995).…”

Section: Discussionmentioning

confidence: 99%

Cadmium Accumulation in Liver and Kidneys and Hepatic Metallothionein and Glutathione Levels in Rana ridibunda, After Exposure to CdCl2

Vogiatzis

Loumbourdis

1998

Arch Environ Contam Toxicol

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Adult female Rana ridibunda were exposed to 200 ppm (mg/l) of cadmium (Cd as CdCl2) dissolved in water for 4, 10, and 30 days. The 96-h LC50 value for Cd was determined to 534 ppm. The concentration of Cd in the liver and kidneys and the effect of Cd on the concentrations of hepatic metallothionein (Mts) and glutathione (GSH), were estimated. Cd accumulated in the liver and kidneys in a time-dependent pattern, with the kidneys accumulating the heavy metal at higher rates after the tenth day of exposure. There was a strong positive correlation of Cd concentration between these two organs. The concentration of Mts and GSH increased with the increase of Cd concentration in the liver, following a time- and Cd-dependence pattern. The concentration of Mts and GSH was positively correlated with the concentration of Cd in the liver. Mts concentration was positively correlated with GSH concentration.

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Section: Discussionmentioning

confidence: 99%

Cadmium Accumulation in Liver and Kidneys and Hepatic Metallothionein and Glutathione Levels in Rana ridibunda, After Exposure to CdCl2

Vogiatzis

Loumbourdis

1998

Arch Environ Contam Toxicol

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“…Of the metals described above, Cu, Zn, and Cd bind to protein(s) at a retention time ϳ1270 s, which corresponds to MW ϳ 13 kDa. Figure 6 shows that the protein(s) at this retention time contain S but not P. Metallothioneins are common proteins that contain Cu, Zn, Cd, and S, do not contain P, and would be expected to be abundant in these liver extracts (22,23). A metallothionein standard also produces a weak UV absorption peak at a retention time corresponding to an apparent molecular weight of 13 kDa, instead of the true molecular weight of ϳ6 kDa (data not shown).…”

Section: Fig 4 Chromatograms Formentioning

confidence: 97%

Measurement of Trace Elements in Proteins Extracted from Liver by Size Exclusion Chromatography-Inductively Coupled Plasma-Mass Spectrometry with a Magnetic Sector Mass Spectrometer

Wang

Dreessen

Wiederin

et al. 2001

Analytical Biochemistry

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“…A high exposure to cadmium causes signifi cant accumulation of this metal in the soft tissues, because a small proportion is excreted, primarily remaining retained in the kidney and liver (Webb & Caín 1982, Torra et al 1994. When cadmium reaches the blood it is retained in the liver, where it stimulates the synthesis of metallothioneins, forming a complex cadmium-metallothionein (Cd-MT), which is directed to the kidney for excretion (Cherian & Goyer 1978, García-Rico et al 1999.…”

Section: Discussionmentioning

confidence: 99%

“…When cadmium reaches the blood it is retained in the liver, where it stimulates the synthesis of metallothioneins, forming a complex cadmium-metallothionein (Cd-MT), which is directed to the kidney for excretion (Cherian & Goyer 1978, García-Rico et al 1999. However, the high bioaccumulation of Cd-MT in the kidney causes nephrotoxic effects, affecting the proximal tubules (Torra et al 1994). Likewise, concentration of 6 μg/g dw in kidney may cause a blockage in the absorption of Zn and Cu, causing various nephropathies (Onosaka et al 1984, Gallant & Cherian 1987, Ohta et al 1989, Kaji et al 1995, López-Alonso et al 2012.…”

Section: Discussionmentioning

confidence: 99%

Cadmium and Lead content in Liver and Kidney tissues of Wild Turkey Vulture Cathartes aura (Linneo, 1758) from Chañaral, Atacama desert, Chile

Alvarado

et al. 2013

Gayana (Concepc.)

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The Atacama region, Chile, presents one of the highest levels of mining exploitation of the country, which leads to high levels of contamination from mine tailings and other related environmental liabilities. One of the most complex situations occurred in the Chañaral city, north of Chile, where for over 50 years mine tailings were dumped on the coast, causing severe damage in the ecosystem. To evaluate the effects on terrestrial biota, we analyzed the concentration of cadmium and lead in tissues of Turkey Vulture (Cathartes aura). The results indicate that accumulation of cadmium in kidney was 10.31 μg/g (SD 8.00, range 0.27 to 20.73 μg/g) while in the liver was 5.24 μg/g (SD 8.00, range 0.49 to 19.70). There values are very high when compared to data for other birds with similar ecological role. In relation to the lead, concentration in liver was 0.86 μg/g (SD 2.03, range 0.15 -7.90), while in kidney was 1.05 μg/g (DS 2.54, range 0.044 to 9.86), values considered within the normal range. It is interesting to analyze from the perspective of the availability of these metals in the mining tailings, where lead (1.57 to 21.2 μg/g) presented higher levels than cadmium (0.061 to 1.085 μg/g). The difference between organs may be related to the role of metallothionein. We discuss the role of Turkey Vulture as a bioindicator of environmental liabilities. KEYWORDS:Ecotoxicology, Heavy Metals, Cathartes aura. RESUMENLa Región de Atacama, Chile, presenta uno de los mayores niveles de explotación minera del país, el cual a su vez genera altos niveles de contaminación por relaves mineros y otros pasivos ambientales relacionados. Una de las más complejas situaciones ocurrió en la ciudad de Chañaral, norte de Chile, donde fueron liberados relaves mineros a sus costas por sobre 50 años, causando graves daños en el ecosistema. Para evaluar los efectos en la biota terrestre, nosotros analizamos la concentración de Cadmio y Plomo en tejidos del Jote de Cabeza Colorada (Cathartes aura). Los resultados indican que la acumulación de Cadmio en el Riñón fue 10,31 μg/g (DS 8,00, rango 0,27 a 20,73 μg/g) mientras en el Hígado fue 5,24 μg/g (DS 8,00, rango 0,49 a 19,70). Estos valores son muy altos si se compara con datos de otras aves de similar rol ecológico. En relación al Plomo, la concentración en Hígado fue de 0,86 μg/g (DS 2,03, rango 0,15 a 7,90), mientras que en Riñón fue de 1,05 μg/g (DS 2,54, rango 0,044 a 9,86), valores considerados dentro del rango normal. Estos resultados son interesantes de analizar desde la perspectiva de la disponibilidad de estos metales en el relave minero, donde el Plomo (1,57 a 21,2 μg/g) presentó mayores niveles que el Cadmio (0,061 a 1,085 μg/g). La diferencia entre órganos puede ser relacionado al rol de las metalotioneinas. Discutimos el rol del Jote de Cabeza Colorada como bioindicador de contaminaciones ambientales.

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Total and metallothionein-bound cadmium in the liver and the kidney of a population in Barcelona (Spain)

Cited by 18 publications

References 19 publications

Cadmium Accumulation in Liver and Kidneys and Hepatic Metallothionein and Glutathione Levels in Rana ridibunda, After Exposure to CdCl2

Cadmium Accumulation in Liver and Kidneys and Hepatic Metallothionein and Glutathione Levels in Rana ridibunda, After Exposure to CdCl2

Measurement of Trace Elements in Proteins Extracted from Liver by Size Exclusion Chromatography-Inductively Coupled Plasma-Mass Spectrometry with a Magnetic Sector Mass Spectrometer

Cadmium and Lead content in Liver and Kidney tissues of Wild Turkey Vulture Cathartes aura (Linneo, 1758) from Chañaral, Atacama desert, Chile

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