Total and speciated urinary arsenic levels in the Spanish population

Serrano, Irene Navarro; Ballesteros, María Teresa Llorente; Pacheco, Silvia Sánchez Fernández; Álvarez, Silvia Izquierdo; Colón, J.L. López

doi:10.1016/j.scitotenv.2016.07.134

Cited by 22 publications

(6 citation statements)

References 27 publications

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“…Also, lack of associations or strong correlations may be related to misclassification of reporting of rice intake using a FFQ that asks about intake over the past year, and not the time period reflective of urinary excretion of arsenic (e.g., the past few days). Fish/seafood consumption is also an important part of the Spanish diet and it contributes to the ingestion of AsB, and tends to dominate exposure to organic arsenic from food intake in the Spanish and other populations with similar gastronomic cultures (Navarro Serrano et al, 2016;Taylor et al, 2016). In this study, the AsB concentrations contributed to over half of the sum of all urinary arsenic species analyzed (i.e.…”

Section: Discussionmentioning

confidence: 69%

Inorganic arsenic exposure and neuropsychological development of children of 4–5 years of age living in Spain

Signes-Pastor

Vioque

Navarrete-Muñoz

et al. 2019

Environmental Research

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Early-life exposure to inorganic arsenic (iAs) may adversely impact health later in life. To date, evidence of iAs adverse effects on children's neurodevelopment comes mainly from populations highly exposed to contaminated water with conflicting results. Little is known about those effects among populations with low iAs exposure from food intake. We investigated the cross-sectional association between exposure to iAs and neurodevelopment scores among children living in Spain whose main route of exposure was diet. Arsenic species concentrations in urine from 400 children was determined, and the sum of urinary iAs, dimethylarsinic acid, and monomethylarsonic acid was used to estimate iAs exposure. The McCarthy Scales of Children's Abilities was used to assess children's neuropsychological development at about 4-5 years of age. The median (interquartile range) of children's sum of urinary iAs, MMA, and DMA was 4.85 (2.74-7.54) μg/L, and in adjusted linear regression analyses the natural logarithm transformed concentrations showed an inverse association with children's motor functions (β, [95% confidence interval]; global scores (-2.29, [-3.95,-0.63]), gross scores (-1.92, [-3.52,-0.31]) and fine scores (-1.54, [-3.06,-0.03]). In stratified analyses by sex, negative associations were observed with the scores in the quantitative index (-2.59, [-5.36, 0.17]) and working memory function (-2.56, [-5.36, 0.24]) only in boys. Our study suggests that relatively low iAs exposure may impair children's neuropsychological development and that sex-related differences may be present in susceptibility to iAs related effects; however, our findings should be interpreted with caution given the possibility of residual confounding.

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Section: Discussionmentioning

confidence: 69%

Inorganic arsenic exposure and neuropsychological development of children of 4–5 years of age living in Spain

Signes-Pastor

Vioque

Navarrete-Muñoz

et al. 2019

Environmental Research

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“…The 4-year-old children’s total seafood intake was primarily fish consumption, which contains predominantly AsB (Molin et al, 2015; Taylor et al, 2016), and thus seafood intake was clearly correlated with the urinary excreted unchanged AsB. There was no evidence of correlation between seafood consumption and i-As or other urinary arsenic species that have been related to potential health effects (Choi et al, 2010; Fort et al, 2014; Navarro Serrano et al, 2016; Navas-Acien et al, 2011). Notably there was no evidence of correlation between the combination of bivalves and crustaceans consumption with urinary i-As or its metabolites despite higher i-As content being commonly reported in bi-valves and crustaceans compared to fish and cephalopods including those marketed in Spain (Fontcuberta et al, 2011; Krishnakumar et al, 2016; Taylor et al, 2016).…”

Section: Discussionmentioning

confidence: 96%

“…Spain is among the highest seafood consumers in Europe (Navarro Serrano et al, 2016; Taylor et al, 2016), and consequently seafood products were in almost all children’s diets included in this study. The 4-year-old children’s total seafood intake was primarily fish consumption, which contains predominantly AsB (Molin et al, 2015; Taylor et al, 2016), and thus seafood intake was clearly correlated with the urinary excreted unchanged AsB.…”

Section: Discussionmentioning

confidence: 99%

Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain

Signes-Pastor

Vioque

Navarrete-Muñoz

et al. 2017

Environmental Research

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Inorganic arsenic (i-As) has been related to wide-ranging health effects in children, leading to lifelong concerns. Proportionally, dietary i-As exposure dominates in regions with low arsenic drinking water. This study aims to investigate the relation between rice and seafood consumption and urinary arsenic species during childhood and to assess the proportion of urinary i-As metabolites. Urinary arsenic species concentration in 400 4-year-old children living in four geographical areas of Spain, in addition to repeated measures from 100 children at 7 years of age are included in this study. Rice and seafood products intake was collected from children’s parents using a validated food frequency questionnaire (FFQ). At 4 years of age, children’s urine i-As and monomethylarsonic acid (MMA) concentrations increased with rice product consumption (p-value = 0.010 and 0.018, respectively), and urinary arsenobetaine (AsB) with seafood consumption (p = 0.002). Four-year-old children had a higher consumption of both rice and seafood per body weight and a higher urinary %MMA (p-value = 0.001) and lower % dimethylarsinic acid (DMA) (p-value = 0.017). This study suggests increased dietary i-As exposure related to rice product consumption among children living in Spain, and the younger ones may be especially vulnerable to the health impacts of this exposure also considering that they might have a lower i-As methylation capacity than older children. In contrast, seafood consumption did not appear to influence the presence of potentially toxic arsenic species in this population of children.

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“…The result further showed that uAs may bind to proteins in the form of iAs. (3) According to the study, oAs was mainly metabolized into other forms instead of iAs in human body (Navarro Serrano et al, 2016; De Loma et al, 2019). Apart from this, oAs are nontoxic or less toxic because it is difficult to transform into highly toxic iAs (Stice et al, 2016; Taylor et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Liu

Han

et al. 2019

Front. Pharmacol.

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High arsenic residues make Cordyceps sinensis a concern in China. Arsenic toxicity is related to its species. Many studies have evaluated the toxicity of total arsenic, but few have studied its species. In this study, the species of arsenic in C. sinensis and its potential health risk were investigated. SEC-HPLC-ICP-MS was used to analysis of arsenic in C. sinensis and unknown arsenic (uAs) was discovered. Additionally, arsenic in C. sinensis was mainly found in alkali-soluble proteins. The trend of arsenic transformation indicated that unknown arsenic in C. sinensis may be converted into free inorganic arsenic, which enhanced toxicity. The result of risk assessment indicated that there were potential health risks of uAs. Hereon, we proposed recommendations for the use of C. sinensis and regulatory recommendations for arsenic standards. This study contributed to the toxicity reveal, safety evaluation, and risk assessment of arsenic in C. sinensis.

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Total and speciated urinary arsenic levels in the Spanish population

Cited by 22 publications

References 27 publications

Inorganic arsenic exposure and neuropsychological development of children of 4–5 years of age living in Spain

Inorganic arsenic exposure and neuropsychological development of children of 4–5 years of age living in Spain

Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

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