Total and Unbound Cefazolin Pharmacokinetics and Pharmacodynamics in Non-Obese and Obese Patients

Antibiotic prophylaxis in cardiac surgery: challenges and future perspectives

“…The presence of augmented adipose tissue may result in modified pharmacokinetics of antibiotics, thereby impacting the distribution and elimination of drugs [24] . Several studies have reported that Cefazolin's pharmacokinetics can be considerably changed by obesity, changing the drug's body concentrations [25][26][27] . Ryu and colleagues conducted a retrospective study in patients to evaluate the results and side effects between 2 groups of patients: those who received a high dosage of cefazolin that was dose-adjusted for body weight and those who received a conventional dose that was not weight-adjusted.…”