Total arterial compliance: the future of cardiovascular risk assessment?

Heitmar, Rebekka

doi:10.1038/jhh.2009.106

Cited by 4 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This method was based on a three-element Windkessel model 14 – 16 , 26 , 29 . In the three-element Windkessel model, it assumed that the heart follows Poiseuille’s Law and the ratio of pressure to volume in the chamber was constant 14 . When the structural changes existed in some disease states, this presumption might not be valid.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Heitmar et al . 14 suggested that some additional parameters, such as arterial pulse pressure waveform, be added to analyze the TAC.…”

Section: Discussionmentioning

confidence: 99%

“…Vascular damage accompanies elevated arterial stiffness and reduced arterial elasticity. Total arterial compliance (TAC) is an evaluation of the arterial compliance in the entire arterial tree 11 , and it reflects the elastic property of the vascular system 12 – 14 . Furthermore, TAC plays an important role in the biomechanics and homeostasis 10 , and it is the main determinant of cardiac afterload, left ventricular function and arterio-ventricular coupling 15 – 19 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of beat-to-beat blood pressure variability on vascular elasticity in hypertensive population

Xia

Liu

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Whether elevated beat-to-beat blood pressure variability (BPV) has an influence on vascular elasticity is confounded and poorly understood. This study hypothesized that the increased BPV could have an adverse effect on the vascular elasticity, as estimated by total arterial compliance (TAC), independent of blood pressure (BP) values. Beat-to-beat BP and TAC were measured in 81 hypertensive patients (experimental population) and in 80 normal adults (control population). Beat-to-beat BPV was assessed by standard deviation (SD), average real variability (ARV), residual standard deviation (RSD) and variation independent of mean (VIM). In experimental population, systolic BPV (SBPV) showed a significant correlation with TAC (SD, r = −0.326, p < 0.001; ARV, r = −0.277, p = 0.003; RSD, r = −0.382, p < 0.001; VIM, r = −0.274, p = 0.003); similarly, SD, RSD and VIM of diastolic BP (DBP) also showed explicit correlation with TAC (r = −0.255, p = 0.006; r = −0.289, p = 0.002; r = −0.219, p = 0.019; respectively). However, in the control population, neither SBPV nor diastolic BPV (DBPV) showed a significant correlation with TAC. Furthermore, in the experimental population, VIM of systolic BP (SBP) was also a determinant of TAC (β = −0.100, p = 0.040) independent of average SBP, DBP, age and body mass index. In conclusion, these data imply that beat-to-beat BPV, especially SBPV, shows an independent correlation with vascular elasticity in hypertensive population.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Moreover, Heitmar et al . 14 suggested that some additional parameters, such as arterial pulse pressure waveform, be added to analyze the TAC.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of beat-to-beat blood pressure variability on vascular elasticity in hypertensive population

Xia

Liu

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…TAC was an assessment of the stiffness of the arteries in the entire arterial tree, [8] and it reflected the elasticity of the vascular system. [9,10] Some studies had demonstrated that TAC played a critical role in predicting CVD. [9–12] Moreover, previous studies had also manifested that TAC was an important determinant of arterial load, left ventricle (LV) afterload, and pulse wave velocities (PWV).…”

Section: Introductionmentioning

confidence: 99%

Association between beat-to-beat blood pressure variability and vascular elasticity in normal young adults during the cold pressor test

Xia

Gao

et al. 2017

Medicine

View full text Add to dashboard Cite

The beat-to-beat blood pressure (BP) monitoring parameters, such as average beat-to-beat BP, BP variability (BPV), could have an influence on the vascular elasticity. This study hypothesized that the elevated beat-to-beat BPV could evoke the reduction of the vascular elasticity independent of BP levels. We measured the beat-to-beat BP recordings and total arterial compliance (TAC), which was used to assess the vascular elasticity, in 80 young healthy adults during the cold pressor test (CPT). The CPT included 3 phases: baseline phase, cold stimulus phase, recovery phase. Six parameters were used to estimate BPV. In bivariate correlation analysis, TAC showed a significant correlation with systolic BP (SBP) and diastolic BP (DBP) in the cold stimulus phase; and 4 indices of SBP variability (SBPV) were associated with TAC (r = 0.271∼0.331, P ≤ 0.015) in the recovery phase; similarly, 2 indices of DBP variability (DBPV) were also correlated with TAC (r = 0.221∼0.285, P ≤ 0.048) in the recovery phase. In multivariate regression analysis, DBPV (β = 0.229, P = 0.001) was a determinant of TAC independent of average DBP, sex, and weight. In addition, both beat-to-beat BP and BPV values increased in the cold stimulus phase (P < 0.01); whereas, the TAC decreased in the cold stimulus phase (P < 0.01). In conclusion, these data suggest that the beat-to-beat DBPV shows an independent association with the vascular elasticity in young normal adults during the CPT.

show abstract

“…Arterial stiffness is a major determinant for the increase in the pulse pressure (PP) and CBP, variables considered risk predictors of myocardial infarction, stroke, and heart failure. In addition, higher cardiovascular morbidity and mortality have been associated with increased CBP, especially in hypertensive diabetics, the elderly, and chronic renal disease patients [ 40 , 41 ]. Thus, advanced age and high BP are the two most important variables for increased arterial thickness and, consequently, arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial

Vilela-Martin

Giollo-Júnior

Chiappa

et al. 2016

Trials

View full text Add to dashboard Cite

BackgroundResistant hypertension (RH) treatment requires an adequate and intense therapeutic approach. However, the results are not always satisfactory despite intensive treatment. Of the different pathophysiological mechanisms involved in the pathogenesis of RH, sympathetic overstimulation and therapies that block the sympathetic system have been widely studied. These approaches, however, are invasive and expensive. Another possible approach is by transcutaneous electrical nerve stimulation (TENS), a noninvasive method that modulates activity by using low-frequency transcutaneous electrical stimulation to inhibit primary afferent pathways. Thus, the current study will evaluate the effect of applying TENS in the cervicothoracic region of subjects with RH and will seek to develop a new low-cost and readily available therapy to treat this group of hypertensive individuals.Methods/designThis is a randomized, single blind (subject), parallel-assignment study controlled with a sham group and including participants aged 40 to 70 years with resistant hypertension. The trial has two arms: the treatment and control (sham group). The treatment group will be submitted to the stimulation procedure (TENS). The sham group will not be submitted to stimulation. The primary outcomes will be a reduction in the peripheral blood pressure and adverse events. The secondary outcomes will be a reduction the central blood pressure. The study will last 30 days. The sample size was calculated assuming an alpha error of 5 % to reject the null hypothesis with a statistical power of 80 %, thereby resulting in 28 participants per group (intervention versus sham).DiscussionIn recent decades, RH has become very common and costly. Adequate control requires several drugs, and in many cases, treatment is not successful. Sympathetic nervous system inhibition by renal denervation and central inhibition have significant effects in reducing BP; however, these treatments are costly and invasive. Another type of sympathetic nervous system inhibition can also be noninvasively achieved by electric current. Therefore, the application of TENS may be a new therapeutic option for treating resistant hypertensive individuals.Trial RegistrationClinical Trials NCT02365974Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-016-1302-8) contains supplementary material, which is available to authorized users.

show abstract

Total arterial compliance: the future of cardiovascular risk assessment?

Cited by 4 publications

References 17 publications

Influence of beat-to-beat blood pressure variability on vascular elasticity in hypertensive population

Influence of beat-to-beat blood pressure variability on vascular elasticity in hypertensive population

Association between beat-to-beat blood pressure variability and vascular elasticity in normal young adults during the cold pressor test

Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial

Contact Info

Product

Resources

About