Total cavopulmonary connection with a new bioabsorbable vascular graft: First clinical experience

Abstract

Initial clinical experience with a novel absorbable graft underlines the potential of this new material to improve cardiac and vascular surgical procedures. In addition, better biocompatibility may reduce permanent implant-related complications. A longer follow-up is needed to assess the long-term effectiveness of biodegradable vascular grafts, including their ability to grow.

Hemodynamic loads distinctively impact the secretory profile of biomaterial-activated macrophages – implications forin situvascular tissue engineering

“…22 PCL-BU was chosen as the biomaterial of interest as it belongs to a class of elastomeric thermoplastic materials that is susceptible to enzymatic and oxidative degradation 11 and has demonstrated its potential for in situ cardiovascular tissue engineering applications. [30][31][32][33][34] Secondly, human THP-1 derived monocytes were seeded in comparable scaffolds (using fibrin as a cell carrier), stimulated to become macrophages and exposed to physiological loading conditions (shear stress, cyclic stretch or a combination thereof ) for 8 days in the bioreactor. Statically cultured macrophage-seeded tubular scaffolds were included as experimental controls.…”

Valved conduits in pediatric cardiac surgery

“…А.Н. Бакулева 5 детям с гемодинамическим единственным желудочком сердца было выполнено формирование полного экстра-кардиального кавапульмонального анастомоза (процеду-ра Фонтена) с использованием кондуита Xeltis [65]. Л.А.…”

“…Л.А. Бокерия и коллеги отмечают отличную функцию кондуита у всех пациентов через 12 мес [65]. Несмотря на эти оптимистичные данные, T. Shinoka в своем сообще-нии высказал обеспокоенность медленной резорбцией Xeltis: в эксперименте на животных элементы полимер-ных материалов сохранялись в течение 53 мес [66].…”

Predicting and understanding collagen remodeling in human native heart valves during early development

“…This is particularly relevant for the 10 field of heart valve tissue engineering, that aims at the development of functional living heart valve replacements with the potential to grow and remodel with patients. Although tissue-engineered heart valves with a proper functionality for up to one year can be developed with current techniques [6,7,8,9], further studies are needed to ensure that these tissues are provided with the 15 correct stimuli for a physiological collagen remodeling, as this is necessary for a correct long-term functionality.…”

“…The effects that mechanical stimuli have on stress fiber remodeling, which are modeled with the functions f ε,a and fε introduced with Eqs. (5) and (7), scale with the maximum cell traction σ max and the parameter k f 1 . The 115 term ϕ m represents the monomeric actin volume fraction, which is related to the stress fiber volume fractions ϕ i sf and the total actin volume fraction φ a via a conservation law for actin monomers:…”