Total cholesterol/HDL cholesterol ratio and monocyte/HDL cholesterol ratio are related with subclinical hypothyroidism in polycystic ovary syndrome

Çakir, İşıl; Şimşek, Yasin

doi:10.1515/tjb-2021-0050

Cited by 2 publications

(6 citation statements)

References 23 publications

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“…MHR is known both as a marker of inflammation and as a prognostic factor for cardiovascular diseases. MHR has been studied in many medical diseases [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. However, there are limited studies in the literature on schizophrenia patients [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Monocyte/HDL Cholesterol Ratios as a New Inflammatory Marker in Patients with Schizophrenia

KILIÇ>

TAŞCI

Yılmaz

et al. 2023

JPM

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Purpose: Monocyte/HDL cholesterol ratio (MHR) is a novel inflammatory marker that is used as a prognostic factor for cardiovascular diseases and has been studied in many diseases. The aim of this study was to investigate the role of inflammatory factors in schizophrenia patients by examining MHR levels and to compare schizophrenia patients and healthy controls in terms of cardiovascular disease risk. Method: A total of 135 participants between the ages of 18–65, 85 diagnosed with schizophrenia, and 50 healthy individuals in the control group were included in this cross-sectional study. Venous blood samples were taken from the participants and CBC parameters and lipid profiles were analyzed. The sociodemographic and clinical data form and positive and negative symptoms scale (PANSS) were administered to all participants. Results: Although monocyte levels were significantly higher in the patient group, HDL-C levels were lower at significant levels. MHR was found to be higher in the patient group compared to the control group at significant levels. When compared to the control group, total cholesterol, triglyceride, WBC, neutrophil, basophil, and platelet levels were higher in the patient group at significant levels, and RBC, hemoglobin, and hematocrit levels were significantly lower. Conclusion: The elevated MHR in patients with schizophrenia may contribute to our understanding that inflammation plays important roles in the pathophysiology of schizophrenia. Additionally, knowing the levels of MHR and considering the recommendations, such as diet and exercise, in the treatment approaches made us think that it might be beneficial in protecting schizophrenia patients against cardiovascular diseases and early death.

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Section: Introductionmentioning

confidence: 99%

Monocyte/HDL Cholesterol Ratios as a New Inflammatory Marker in Patients with Schizophrenia

KILIÇ>

TAŞCI

Yılmaz

et al. 2023

JPM

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“…The ratio of TC/HDL or LDL/HDL is the surrogate for ApoB/ApoA 14 . In a study of 99 PCOS patients conducted by Cakir and Simsek, the ratio of TC/HDL was significantly higher 9 . In this study, the ratios of TC/HDL and LDL/HDL were significantly higher in the PCOS group than those in the control group.…”

Section: Discussionmentioning

confidence: 94%

“…Yılmaz et al found that NLR was higher in the PCOS group than that in the control group 17 . Another study reported that NLR was significantly higher 9 . In this study, no significant differences were found for NLR between the PCOS and control groups.…”

Section: Discussionmentioning

confidence: 95%

“…In this study, the values for weight, BMI, WC, IR, and hirsutism scores were higher in the PCOS group than those in the control group, which is consistent with the literature data. HDL cholesterol has anti-inflammatory, antioxidant, and antithrombotic effects 9 . Monocyte/HDL is a marker that has previously been associated with cardiovascular events 10 .…”

Section: Discussionmentioning

confidence: 99%

“…HDL cholesterol has anti-inflammatory, antioxidant, and antithrombotic effects 9 . Monocyte/HDL is a marker that has previously been associated with cardiovascular events 10 .…”

Section: Discussionmentioning

confidence: 99%

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Total cholesterol/high-density lipoprotein and inflammatory parameters in patients with polycystic ovary syndrome

Gülücü

CAN

2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: In this study, the hormone profile, lipid profile, and inflammatory parameters of patients with polycystic ovary syndrome were compared with those of non-polycystic ovary syndrome patients to determine predictive markers in young polycystic ovary syndrome patients who have not yet had children. METHODS: Patients' age, height, weight, body mass index, waist circumference, degree of hirsutism, and ultrasound findings were recorded. Hormone profile, lipid levels, ratio of complete blood count parameters, monocyte/high-density lipoprotein ratio, and total cholesterol/high-density lipoprotein ratio were compared between groups. RESULTS: No statistically significant differences were found between groups in terms of age, weight, waist circumference, body mass index, and dysmenorrhea (p>0.05). A significant relationship was found between the height and the degree of hirsutism in the groups (p<0.05). It was found that prolactin, total testosterone, and dehydroepiandrosterone sulfate levels were statistically significantly higher in the polycystic ovary syndrome group compared to the control group. The polycystic ovary syndrome group had hemoglobin, leukocytes, lymphocytes, neutrophils, platelets, and statistically higher ratios of total cholesterol/high-density lipoprotein, Low-density lipoprotein/high-density lipoprotein, and triglycerides/highdensity lipoprotein. No statistically significant relationships were found between homeostatic model assessment insulin resistance, neutrophilto-lymphocyte ratio, and monocyte-to-high-density lipoprotein ratio between the groups (p<0.05). There was no significant difference in systemic immune inflammation index values between the groups. CONCLUSION: Polycystic ovary syndrome patients are at risk for short-and long-term complications, and the use of the total cholesterol/high-density lipoprotein, Low-density lipoprotein/high-density lipoprotein, and triglycerides/high-density lipoprotein ratios in clinical practice during the follow-up of these patients may allow easy follow-up for patients. The health status of polycystic ovary syndrome patients can be objectively determined by tracking these outcomes at regular intervals.

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Total cholesterol/HDL cholesterol ratio and monocyte/HDL cholesterol ratio are related with subclinical hypothyroidism in polycystic ovary syndrome

Cited by 2 publications

References 23 publications

Monocyte/HDL Cholesterol Ratios as a New Inflammatory Marker in Patients with Schizophrenia

Monocyte/HDL Cholesterol Ratios as a New Inflammatory Marker in Patients with Schizophrenia

Total cholesterol/high-density lipoprotein and inflammatory parameters in patients with polycystic ovary syndrome

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