Total endoscopic management of a patient with urinary bladder leiomyosarcoma presenting with dysuria: A case report

Abstract

The pathophysiology of bladder leiomyosarcoma, a rare disease with aggressive mesenchymal tumor, is not certain, but its main symptoms are hematuria, dysuria and abdominal pain. Cases described in the literature are few. This report describes a case of a leiomyosarcoma of the urinary bladder in a 49-year-old woman. After CT scanning revealed a heterogeneously enhanced 4-cm mass involving the bladder neck and anterior wall, further examinations detected no metastatic lesion. Cystoscopy and transurethral resection of bladder tumor (TURBT) were performed. The histopathological diagnosis was leiomyosarcoma. Postoperative period was uneventful. The patient experienced complete resolution of urologic symptoms. Repeat-TURBT was performed 70 days after first surgery. The patient has remained disease-free 18 months after surgery.

Leiomyosarcoma of the bladder: A review and a report of four further cases

“…Retinoblastoma gene mutation, Li-Fraumeni syndrom, NF-1 gene mutation, history of pelvic irradiation, cyclophosphamide use, chronic bladder inflammation, and the combination of bladder leiomyosarcoma with urothelial carcinoma have been reported in literature. Conversion of leiomyoma to leiomyosarcoma is exceptional [ [2] , [3] , [4] , 7 , 8 ]. None of these risk factors were found in our study.…”