Total flavonoids of Mosla scabra leaves attenuates lipopolysaccharide-induced acute lung injury via down-regulation of inflammatory signaling in mice

Chen, Jing; Wang, Jingbo; Yu, Chunjing; Chen, Liqing; Xu, Pan; Yu, Wen-Ying

doi:10.1016/j.jep.2013.05.020

Cited by 27 publications

(17 citation statements)

References 35 publications

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“…Regarding the mechanism of action, this flavonoid reduced LPS-induced activation of the MAPK and NFκB pathways [99]. Other works have also studied flavonoids for their beneficial effects in LPS-induced ARDS [97].…”

Section: Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 99%

“…Although the control of lung ventilation as a protection strategy has considerably reduced mortality, no specific treatment is available; the number of young people who died because of ARDS is high and the treatment only considered the cause. Some evidence suggests that substances of the flavonoid class may have a modulatory effect in ARDS, but most of the studies are in experimental models [97,98].…”

Section: Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 99%

“…Models of lipopolysaccharide-induced lung inflammation are also used to study the anti-inflammatory effects of flavonoids because LPS is present in the membrane of gram-negative bacteria and LPS is considered one of the main risk factors for ARDS [97]. In a study evaluating the protective activity of the flavonoid luteolin (19) in animals that received LPS to mimic ARDS, authors showed an important reduction of lung hemorrhage, neutrophilic inflammation as well as interstitial edema in distal lung parenchyma and alveolar spaces [99].…”

Section: Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 99%

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Structure-Activity Association of Flavonoids in Lung Diseases

et al. 2014

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Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and chalcones according to their chemical structures. They are abundantly found in Nature and over 8,000 flavonoids have from different sources, mainly plant materials, have been described. Recently reports have shown the valuable effects of flavonoids as antiviral, anti-allergic, antiplatelet, antitumor, antioxidant, and anti-inflammatory agents and interest in these compounds has been increasing since they can be helpful to human health. Several mechanisms of action are involved in the biological properties of flavonoids such as free radical scavenging, transition metal ion chelation, activation of survival genes and signaling pathways, regulation of mitochondrial function and modulation of inflammatory responses. The anti-inflammatory effects of flavonoids have been described in a number of studies in the literature, but not frequently associated to respiratory disease. Thus, this review aims to discuss the effects of different flavonoids in the control of lung inflammation in some disorders such as asthma, lung emphysema and acute respiratory distress syndrome and the possible mechanisms of action, as well as establish some structure-activity relationships between this biological potential and chemical profile of these compounds.

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Section: Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 99%

Section: Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 99%

Section: Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 99%

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Structure-Activity Association of Flavonoids in Lung Diseases

et al. 2014

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“…It reported that total flavonoids of Mosla scabra (MF) leaves could attenuate pulmonary inflammation in mice with LPS-induced ALI, and the protective effect of MF in ALI might be related to its suppression of NF- κ B and MAPK activation and, subsequently, caused a remarkable reduction in inflammatory cell infiltration and inflammatory cytokine secretion in lung tissues [39]. Also, luteolin suppresses inflammatory mediator expression by blocking the Akt/NF κ B pathway in acute lung injury induced by lipopolysaccharide [40].…”

Section: Discussionmentioning

confidence: 99%

Rabdosia japonica var. glaucocalyx Flavonoids Fraction Attenuates Lipopolysaccharide‐Induced Acute Lung Injury in Mice

Chu

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Rabdosia japonica var. glaucocalyx (Maxim.) Hara, belonging to the Labiatae family, is widely used as an anti-inflammatory and antitumor drug for the treatment of different inflammations and cancers. Aim of the Study. To investigate therapeutic effects and possible mechanism of the flavonoids fraction of Rabdosia japonica var. glaucocalyx (Maxim.) Hara (RJFs) in acute lung injury (ALI) mice induced by lipopolysaccharide (LPS). Materials and Methods. Mice were orally administrated with RJFs (6.4, 12.8, and 25.6 mg/kg) per day for 7 days, consecutively, before LPS challenge. Lung specimens and the bronchoalveolar lavage fluid (BALF) were isolated for histopathological examinations and biochemical analysis. The level of complement 3 (C3) in serum was quantified by a sandwich ELISA kit. Results. RJFs significantly attenuated LPS-induced ALI via reducing productions of the level of inflammatory mediators (TNF-α, IL-6, and IL-1β), and significantly reduced complement deposition with decreasing the level of C3 in serum, which was exhibited together with the lowered myeloperoxidase (MPO) activity and nitric oxide (NO) and protein concentration in BALF. Conclusions. RJFs significantly attenuate LPS-induced ALI via reducing productions of proinflammatory mediators, decreasing the level of complement, and reducing radicals.

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“…It is characterized by neutrophil influx, alveolar-capillary barrier damage leading to interstitial edema, and the impairment of respiratory function [3,4]. While great advances in understanding the pathophysiology of ALI have been reported to date, no effective medicine is available for ALI, and it remains the leading cause of morbidity and mortality in critically ill patients [5,6].…”

Section: Introductionmentioning

confidence: 99%

Spiraea prunifolia var. simpliciflora Attenuates Oxidative Stress and Inflammatory Responses in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury and TNF-α-Stimulated NCI-H292 Cells

Lee

Shin

et al. 2020

Antioxidants

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Spiraea prunifolia var. simpliciflora (SP) is traditionally used as an herbal remedy to treat fever, malaria, and emesis. This study aimed to evaluate the anti-oxidative and anti-inflammatory properties of the methanol extract of SP leaves in tumor necrosis factor (TNF)-α-stimulated NCI-H292 cells and in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. SP decreased the number of inflammatory cells and the levels of TNF-α, interleukin (IL)-1β, and IL-6 in the bronchoalveolar lavage fluid, and inflammatory cell infiltration in the lung tissues of SP-treated mice. In addition, SP significantly suppressed the mRNA and protein levels of TNF-α, IL-1β, and IL-6 in TNF-α-stimulated NCI-H292 cells. SP significantly suppressed the phosphorylation of the mitogen-activated protein kinases (MAPKs) and p65-nuclear factor-kappa B (NF-κB) in LPS-induced ALI mice and TNF-α-stimulated NCI-H292 cells. SP treatment enhanced the nuclear translocation of nuclear factor erythroid 2-related factor (Nrf2) with upregulated antioxidant enzymes and suppressed reactive oxygen species (ROS)-mediated oxidative stress in the lung tissues of LPS-induced ALI model and TNF-α-stimulated NCI-H292 cells. Collectively, SP effectively inhibited airway inflammation and ROS-mediated oxidative stress, which was closely related to its ability to induce activation of Nrf2 and inhibit the phosphorylation of MAPKs and NF-κB. These findings suggest that SP has therapeutic potential for the treatment of ALI.

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Total flavonoids of Mosla scabra leaves attenuates lipopolysaccharide-induced acute lung injury via down-regulation of inflammatory signaling in mice

Cited by 27 publications

References 35 publications

Structure-Activity Association of Flavonoids in Lung Diseases

Structure-Activity Association of Flavonoids in Lung Diseases

Rabdosia japonica var. glaucocalyx Flavonoids Fraction Attenuates Lipopolysaccharide‐Induced Acute Lung Injury in Mice

Spiraea prunifolia var. simpliciflora Attenuates Oxidative Stress and Inflammatory Responses in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury and TNF-α-Stimulated NCI-H292 Cells

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