2023
DOI: 10.3390/antiox12040819
|View full text |Cite
|
Sign up to set email alerts
|

Total Flavonoids of Rhizoma Drynariae Mitigates Aflatoxin B1-Induced Liver Toxicity in Chickens via Microbiota-Gut-Liver Axis Interaction Mechanisms

Abstract: Aflatoxin B1 (AFB1) is a common mycotoxin that widely occurs in feed and has severe hepatotoxic effects both in humans and animals. Total flavonoids of Rhizoma Drynaria (TFRD), a traditional Chinese medicinal herb, have multiple biological activities and potential hepatoprotective activity. This study investigated the protective effects and potential mechanisms of TFRD against AFB1-induced liver injury. The results revealed that supplementation with TFRD markedly lessened broiler intestinal permeability by inc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
6
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 23 publications
(11 citation statements)
references
References 71 publications
0
6
0
Order By: Relevance
“…These types of flavonoids are also known to work as potential antioxidants and also improve the antioxidant properties of food by restricting the activity of other oxidases ( 46 , 56 ). Due to erythrocyte membrane malfunction, various types of flavonoids in the diet diminish lipid peroxidation and the permeability of K ( 57 ). The increasing use of cereals as livestock feed creates a very competitive situation with human feed.…”
Section: Discussionmentioning
confidence: 99%
“…These types of flavonoids are also known to work as potential antioxidants and also improve the antioxidant properties of food by restricting the activity of other oxidases ( 46 , 56 ). Due to erythrocyte membrane malfunction, various types of flavonoids in the diet diminish lipid peroxidation and the permeability of K ( 57 ). The increasing use of cereals as livestock feed creates a very competitive situation with human feed.…”
Section: Discussionmentioning
confidence: 99%
“…However, melatonin can decrease microbiota-derived LPS and hepatocyte ferroptosis by modulating the gut microbiota [ 84 ]. The total flavonoids of Rhizoma Drynaria can prevent oxidative stress and hepatic lipid deposition, reverse hepatic ferroptosis by improving the host intestinal microenvironment, and play a protective role in aflatoxin B1-induced liver damage [ 85 ]. Daidzein, released by gut microbial β-galactosidases, can suppress hepatocyte ferroptosis by reducing farnesyl diphosphate synthase expression [ 86 ].…”
Section: Advanced Studies On the Correlation Between The Gut Microbio...mentioning
confidence: 99%
“…The common features of fungal toxins in humans and animals mainly include liver, kidney, and intestinal injury, and even immunosuppression, which are partly caused by cellular inflammation, oxidative stress, apoptosis, autophagy, ferroptosis, and other forms of cell death [8,[12][13][14][15]. Recent studies showed that mycotoxins can induce liver toxicity, acute kidney injury, or intestinal damage by promoting ferroptosis, manifested by the death of tubule epithelial cells and hepatocytes, and damage to the intestinal barrier function and gut microbial homeostasis [12,15,16].…”
Section: Introductionmentioning
confidence: 99%
“…The common features of fungal toxins in humans and animals mainly include liver, kidney, and intestinal injury, and even immunosuppression, which are partly caused by cellular inflammation, oxidative stress, apoptosis, autophagy, ferroptosis, and other forms of cell death [8,[12][13][14][15]. Recent studies showed that mycotoxins can induce liver toxicity, acute kidney injury, or intestinal damage by promoting ferroptosis, manifested by the death of tubule epithelial cells and hepatocytes, and damage to the intestinal barrier function and gut microbial homeostasis [12,15,16]. Interestingly, treatment of cells with the ferroptosis inhibitor ferrostatin-1 significantly restored the toxicity of mycotoxins (such as T-2 toxin) and also found that T-2 toxin triggered ferroptosis by inducing ROS, suggesting that ferroptosis is related to T-2 toxin-related toxicity and could be a potential target for the treatment of mycotoxicosis [17].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation