Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa

Janas–Kozik, Małgorzata; Krupka-Matuszczyk, I.; Malinowska-Kolodziej, Izabela; Lewin–Kowalik, Joanna

doi:10.1016/j.regpep.2006.11.005

Cited by 49 publications

(30 citation statements)

References 16 publications

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“…We speculate that the lower ghrelin levels in obesity are part of negative feedback to inhibit appetite and body weight, but not the primary cause of obesity [15] . This is also supported by the fact that circulating ghrelin levels increase in anorexia and cachexia [16][17][18] . However, animals without ghrelin do not have significantly altered body weight or food intake when compared with their wild-type littermates [19,20] .…”

Section: Discussionmentioning

confidence: 76%

Factors associated with fasting plasma ghrelin levels in children and adolescents

Zou

Li²,

Zhao³

2008

WJG

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INTRODUCTIONGhrelin, recently isolated from rat and human stomachs, is an endogenous ligand for growth hormone secretagogue receptor (GHSR) type 1a [1,2] . Recent studies have shown that ghrelin is secreted from hypothalamus, pituitary, endocrine pancreas islets, bowel, kidney, heart and testis [1,2] . Besides stimulating GH secretion, ghrelin has been reported to have other endocrine and nonendocrine actions, including stimulation of lactotroph and corticotroph secretion, effects on the gonadal axis, cardiovascular activity, influence on behavior and sleep, modulation of cell proliferation, repression of apoptosis, and orexigenic effects [3][4][5][6][7] . However, most of these studies used animal models and there were some discrepancies in the results. Thus, the regulation of ghrelin secretion and its specific role in endocrinology in humans, including the gonadal axis, insulin resistance, energy balance and obesity, are not completely understood.In this study, we measured plasma ghrelin levels in Chinese children and adolescents, analyzed their associated factors, and investigated the role of ghrelin in obesity, insulin resistance and reproductive physiology. MATERIALS AND METHODS Materials METHODS:A total of 283 subjects aged 4.8-15.8 year were enrolled. Fasting blood samples were collected and plasma ghrelin levels were measured by radioimmunoassay. Fasting glucose (FG), fasting insulin (FI), baseline testosterone (T), estradiol (E2), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT) and uric acid (UA) were measured. Body mass index (BMI), insulin resistance by homeostasis model (HOMA-IR) and beta cell function by homeostasis model (HOMA-β) were calculated. RESULTS:The median ghrelin level was 290 ng/L (15.0-1325.0 ng/L). Bivariate correlation analysis showed that ghrelin levels were inversely correlated with BMI, ALT, TG, UA, LH, FI and HOMA-IR (all P < 0.05). No other significant correlation was found between ghrelin levels and age, gender, TC, E2, FSH, PRL, FG and HOMA-β. Stepwise multiple regression analysis showed that only BMI and FI were independent determinants of plasma ghrelin levels in these children and adolescents (P = 0.018 and P = 0.046, respectively), which explained 25.4% of the variance. CONCLUSION:These data suggest that the lower ghrelin levels in obese subjects may be the result of obesity and hyperinsulinemia, which is very common in obese subjects. Moreover, ghrelin may regulate human

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Section: Discussionmentioning

confidence: 76%

Factors associated with fasting plasma ghrelin levels in children and adolescents

Zou

Li²,

Zhao³

2008

WJG

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“…Therefore, elucidating the underlying neuroendocrine mechanisms of anorexia nervosa is pivotal for the pharmacotherapy of this disease. In female patients with anorexia nervosa, morning fasting total ghrelin level was significantly higher than those in control Nakai et al, 2003;Tolle et al, 2003;Broglio et al, 2004a;Tanaka et al, 2004;Hotta et 464 al., 2004;Germain et al, 2007;Janas-Kozik et al, 2007) and constitutionally thin subjects (Tolle et al, 2003;Miljic et al, 2006Miljic et al, , 2007Germain et al, 2007). In addition, postprandial decline of plasma total ghrelin response to food intake was lost in these female patients with anorexia nervosa (Nedvídková et al, 2003).…”

Section: Ghrelin Gene Products In Food Intake and Gut Motilitymentioning

confidence: 93%

Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility

et al. 2009

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“…Conversely, total ghrelin levels are elevated in situations of negative energy balance but can be restored by weight regain (Janas-Kozik et al, 2007;Otto et al, 2001;Soriano-Guillen et al, 2004). In patients suffering from anorexia nervosa, total plasma ghrelin concentrations of underweight subjects are increased and tend to normalize with the recovery of body weight (Otto et al, 2001;Otto et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

Verhagen¹,

Egecioglu²,

Luijendijk³

et al. 2011

European Neuropsychopharmacology

107

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Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa

Cited by 49 publications

References 16 publications

Factors associated with fasting plasma ghrelin levels in children and adolescents

Factors associated with fasting plasma ghrelin levels in children and adolescents

Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

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