Total Hip Arthroplasty in Hemophilia Patients: A Mid‐term to Long‐term Follow‐up

Wu, Guoli; Zhai, Jiliang; Feng, Bin; Bian, Yanyan; Xu, Chi

doi:10.1111/os.12354

Cited by 21 publications

(19 citation statements)

References 26 publications

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“…14 By an intraindividual comparison, our case showed a reduction in total FIX consumption using eftrenonacog alfa versus pdFIX and switching from the standard half-life to the EHL product did not increase costs, in contrast with data from real-world analysis during prophylaxis. 8 Finally, EHL allowed higher compliance in long-term prophylaxis and helped to maintain the benefit from surgery, which is the main issue with orthopedic procedure in patients with hemophilia [4]. F I G U R E 2 Comparison in terms of cost between the two surgical procedures: cost of antihemorrhagic therapy (A), cost of hospitalization and RBC transfusions (B), and total cost (C)…”

Section: Discussionmentioning

confidence: 99%

“…The most commonly affected joints are knees, elbows, and ankles , and nonetheless, shoulders and hips can be damaged to some extent . Orthopedic surgery experiences in patients with hemophilia are limited . Like all invasive procedure in this kind of patients, orthopedic surgery requires prophylactic administration of the missing factor both at preoperative and postoperative level.…”

Section: Introductionmentioning

confidence: 99%

“…2 Orthopedic surgery experiences in patients with hemophilia are limited. [3][4][5] Like all invasive procedure in this kind of patients, orthopedic surgery requires prophylactic administration of the missing factor both at preoperative and postoperative level. Recently, extended half-life (EHL) concentrates for hemophilia A and B are being introduced in the prophylaxis and treatment of bleeding.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Extended half‐life rFIX in major surgery—How to improve clinical practice: An intraindividual comparison

Valeri¹,

Giacchello²,

Dainese³

et al. 2020

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Extended half‐life rFIX in major surgery—How to improve clinical practice: An intraindividual comparison

Valeri¹,

Giacchello²,

Dainese³

et al. 2020

Clinical Case Reports

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show abstract

“…Perioperative blood loss, pseudotumor recurence and infection were also important matters that the surgons concerned. Though uncontrolled perioperative bleeding is a less serious problem for surgeons with therapeutic clotting factors became available, The perioperative blood loss hemophilia patients still be higher than that of non hemophilia patients in the same kind of operation [21,22].There also has a high blood transfusion rate in our series. Standardized application of coagulation factors, precise operative procedure and anti brinolytic agents are all important steps to control bleeding.…”

Section: Discussionmentioning

confidence: 72%

Outcome of surgical management of hemophilic pseudotumor: Review of 9 Cases from single-center

Yao

Xue

Wang

et al. 2020

Preprint

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Background: Pseudotumours are a rare and serious complication of haemophilia, A slowly growing pseudotumour frequently destroys structures of bone and soft tissues. Surgical resection is the primary method for treatment of proximal pseudotumours. The purpose of this retrospective study was to evaluate the operative methods and clinical results of surgical treatment for those rare cases.Methods: We reviewed nine patients with hemophilic pseudotumours, who received surgical resection treatment in our hospital. The age range was 20-51 years. All operations were performed by one group surgeons. The method of operation depends on the origin and the extent of pseudotumor involvement. With the supplementary of recombinant coagulation factor VIII, six cases received complete resection; one received cytoreduction surgery as the pseudotumor closing to iliac vessel and nerve; two cases received complete resection and construction as bone destruction. Factor substitution was maintained for 14 days. Results: In our series, the average intraoperative blood loss volume was 710±35 ml(range ,240-2100ml). Six patients received blood transfusion during perioperative period. All wounds healed smoothly, no infection or chronic sinus formation. There is no iatrogenic vascular nerve injury in our series. Complete follow-up was performed in all patients. Mean follow-up duration was 14.5months (range, 6–26months). One patient with pseudotumor in the thigh had a recurrence of one year after operation, then secondary operation was performed, Conclusions: Surgical resection for haemophilic pseudotumours is an effctive and safe method . The choice of surgical procedure must be individualized according to the localization and the progress of pseudotumor. However, as relatively few cases and shorter follow-up time in our series. The long-term effects of these patients need further follow-up.

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“…For patients with increased bleeding tendency, the most frequent complications are secondary haemorrhage requiring revision, as well as infection and dislocation [10]. Once a disease such as haemophilia or autoimmune thrombocytopenia has been identified and the advice of a haematologist has been sought, there is a major reduction in the rate of complications [11,12,15].…”

Section: Haemophiliamentioning

confidence: 99%

Total Hip Arthroplasty in Patients with Coagulopathy

Roth

Thiele

2019

Z Orthop Unfall

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Prior to a surgical intervention, the examination of patient coagulation disorders is unfortunately often underestimated. While patients with a haemophilia A or B are usually aware of the congenital tendency to bleed, disorders of increased blood coagulation, thrombophilia, are frequently undetected. Therefore, complications caused by thromboses and embolisms after total hip arthroplasty are far more common than uncontrollable post-operative bleeding. Patients with liver cirrhosis are considered to be particularly complicated and their coagulation status can be difficult to manage. This article describes the most common pathological coagulation disorders and provides information to identify them preoperatively. Furthermore, surgical strategy considerations for the use of certain implant types in this patient group are discussed.

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Total Hip Arthroplasty in Hemophilia Patients: A Mid‐term to Long‐term Follow‐up

Cited by 21 publications

References 26 publications

Extended half‐life rFIX in major surgery—How to improve clinical practice: An intraindividual comparison

Extended half‐life rFIX in major surgery—How to improve clinical practice: An intraindividual comparison

Outcome of surgical management of hemophilic pseudotumor: Review of 9 Cases from single-center

Total Hip Arthroplasty in Patients with Coagulopathy

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