Total hip arthroplasty in sickle cell disease patients in a developing country

Functional Outcome of Total Hip Arthroplasty in Teenagers with End Stage Avascular Necrosis of the Head of Femur Resulting from Sickle Cell Disease

“…There was statistically significant improvement in HHS and OHS with p-value < 0.0001. This is consistent with the findings of Azam MQ, Sadat-Ali M, Ugbeye ME, et al, Katchy,et al and Salihu MN,et al [9,15,22,23].…”

“…A mean age of 16.8 +/-2.0 years was recorded in this study with a range of 12 years-19 years. This was similar to the findings of Patel NK, et al where a mean age of 17 years was recorded with similar range.1 in the study by Ugbeye, et al, no patient required adductor tenotomy [15]. This is contrary to our findings as there was a need for adductor tenotomy in 28 hips.…”

“…Our study showed female preponderance in the ratio of 2.5: 1. Patel NK, et al, Ugbeye ME, et al and Buddhdev PK and colleagues also recorded higher incidences in females than male [1,15,19]. This may not be unrelated with earlier surgery was required in 7 patients for aseptic loosening and in 1 patient due to late infection [9].…”

“…Patients present with advanced stage in our environment as early as 12 years of age. Functional limitations with or without deformities from these complications of sickle cell disease often require Total Hip Arthroplasty (THA) to improve outcome [15].…”

Delayed surgical diagnosis and treatment of severe sickle cell arthropathy: The need to raise clinicians’ awareness

“…Sickle cell disease (SCD) is an inherited hemoglobinopathy that can cause major systemic complications. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 During hypoxia, the defective haemoglobin causes erythrocyte deformity, which consequently creates vaso-occlusive crisis and causes significant pain, the leading cause of SCD hospitalisation. 1 , 4 , 16 SCD negatively impacts the cardiovascular, respiratory, gastrointestinal, renal, neurologic, ocular and skeletal systems.…”