Total hip replacement outcomes: does psoriasis matter?

Abstract

cartilage degeneration, subchondral sclerosis, and osteophyte formation in both rat and rabbit ACLT and Meniscectomy models. The underlying initiating mechanism in surgically-induced OA models was found to be the altered mechanical loading which is the same initiating cause in human secondary OA. Conclusions: All animal models and induction mechanisms result in morphological changes that resemble human pathology in some stages of the disease. Differences are particularly in time of onset of the disease and the speed of disease progression. Moreover, molecular mechanisms of joint structural damage are distinct in different animal models and induction mechanisms. Each animal model and induction mechanism used in OA research has its own advantages and disadvantages. Thus, choosing the best model which mimics human etiology and addresses the aim of the study seems to be a crucial step in conducting research in this area. Hopefully, the present study provides a framework for choosing the best animal model and paves the way for the development of novel disease-modifying agents.