Total intravenous anaesthesia with propofol and alfentanil by computer‐assisted infusion

Schüttler, J.; Kloos, S.; Schwilden, H.; Stoeckel, H.

doi:10.1111/j.1365-2044.1988.tb09059.x

Cited by 170 publications

(63 citation statements)

References 10 publications

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“…Rapid and smooth recovery from propofol anesthesia is reported in man [12,22,23], goats [5], sheep [13] and horses [15][16][17][18]. Time required for recovery in this study approximated to that of the horse administered xylazine 1.0 mg/kg followed by propofol 2.0 mg/kg in other study [16], and recovery was calm and smooth like other reports.…”

supporting

confidence: 74%

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Clinical Observations during Induction and Recovery of Xylazine-Midazolam-Propofol Anesthesia in Horses

et al. 2003

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ABSTRACT. To evaluate clinical usefulness of xylazine (1.0 mg/kg)-midazolam (20 µg/kg)-propofol (3.0 mg/kg) anesthesia in horses, 6 adult Thoroughbred horses were examined. The quality of induction varied from poor to excellent and 5 out of 6 horses presented myotonus in the front half of the body. However, paddling immediately after induction observed in other reports of equine propofol anesthesia was not observed. Recovery time was 35.3 ± 9.3 min and the quality of recovery was calm and smooth in all horses. Respiration rate decreased after induction and hypoxemia was observed during lateral recumbency. Heart rate also decreased after induction, however mean arterial blood pressure was maintained above approximately 100 mmHg. KEY WORDS: equine, intravenous anesthesia, propofol.J. Vet. Med. Sci. 65 (7): [805][806][807][808] 2003 The intravenous anesthetic, propofol (2,6-diisopropylphenol) has been widely used for total intravenous anesthesia of human beings [12,20,22] and some animals [9,11,13]. The drug is characterized by short duration of action with little cumulative effects, easiness of anesthetic depth control and rapid recovery [4,12]. There is a number of reports of anesthesia using propofol also in horses [1,3,[15][16][17][18], in many of these reports, undesirable anesthesia-induction characteristics, i.e., excitement, increased muscle activities and paddling in the early recumbent phase were observed [3,[15][16][17]. For anesthesia induction in horses, safety of both personnel and horse is an important subject. Therefore, establishment of the anesthesia method without such undesirable characteristics is necessary for the clinical application of propofol to horses.In this research, midazolam, a benzodiazepine derivative, was used together with xylazine for premedication of propofol anesthesia of a horse, and the behavior of horses during anesthetic induction and recovery and their effects on the cardiopulmonary function were characterized.Six male 2-years-old (28 ± 1 months of age) healthy Thoroughbred horses trained for rearing weighing 469 ± 24 kg were used. Horses were fasted for 12 hr before anesthesia and freely given water. The experiments were conducted according to the guidelines established by the Experimental Animal Committee, Japan Racing Association.Five min after premedication with xylazine (1.0 mg/kg; Celactar, Bayer, Tokyo, Japan) follwed by midazolam (20 µg/kg; Dormicum, Yamanouchi, Tokyo, Japan) 10 min later, horses received a 3 min in duration intravenous injection of 1% propofol (3.0 mg/kg; Rapinovet, Mallinckrodt Veterinary, Mundelein, U.S.A.) solution.Horses were restrained by a swing-door induction system and propofol was administred. After the horses attained a sternal recumbency, the swing-door was opened and horses were turned to lateral recumbency. Following endotracheal intubation, horses were transported to the recovery room by hoist. In the recovery room, horses were placed in right lateral recumbency on a mat and spontaneously inhaled room air. After appearance of the ...

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confidence: 74%

“…The intravenous anesthetic, propofol (2,6-diisopropylphenol) has been widely used for total intravenous anesthesia of human beings [12,20,22] and some animals [9,11,13]. The drug is characterized by short duration of action with little cumulative effects, easiness of anesthetic depth control and rapid recovery [4,12].…”

mentioning

confidence: 99%

Clinical Observations during Induction and Recovery of Xylazine-Midazolam-Propofol Anesthesia in Horses

et al. 2003

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“…Therefore, target concentrations will not be precisely attained in each subject. A mean variation of measured to target concentration of 20 to 30% is expected with a CACI system (Glass et al 1990;Shafer et al 1990;Schuttler et al 1988). The mean performance error and the mean absolute performance error in this study were less than 30%.…”

Section: Discussionmentioning

confidence: 47%

Does Ketamine-Mediated N-methyl-D-aspartate Receptor Antagonism Cause Schizophrenia-like Oculomotor Abnormalities?

Radant

Bowdle

Cowley

et al. 1998

Neuropsychopharmacology

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“…Thus, use of data from this study has allowed a comprehensive evaluation of the predictive performance of three models in this study. It has been suggested that for a TCI system to be clinically acceptable, MDPE should be no greater than 10-20%, MDAPE should be in the region of 20-30% and maximal variation should not exceed 50-60% [12]. Based on these criteria, and the ranges observed in Table 3, only the White model meets all three requirements.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the predictive performance of three pharmacokinetic models for propofol using measured values obtained during target‐controlled infusion

Glen

White

2014

Anaesthesia

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SummaryWe compared the predictive performance of the existing Diprifusor and Schnider models, used for target-controlled infusion of propofol, with a new modification of the Diprifusor model (White) incorporating age and sex covariates. The bias and inaccuracy (precision) of each model were determined using computer simulation to replicate the infusion profiles in an earlier study of 41 patients undergoing surgery with propofol administered by target-controlled infusion and in which timed, measured blood propofol concentrations were available. Bias with the White model (5%) was significantly less (p < 0.0001) than with the Diprifusor (16%) or Schnider (15%) models. The White model showed a significant improvement in accuracy (inaccuracy 19%, p < 0.0001) relative to the Diprifusor (26%). Temporal changes were such that with all three models, bias differed at induction and recovery. None of the models accounted fully for the extent of inter-individual variation in propofol clearance, but the improved performance with the White model suggests it has merit.

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Total intravenous anaesthesia with propofol and alfentanil by computer‐assisted infusion

Cited by 170 publications

References 10 publications

Clinical Observations during Induction and Recovery of Xylazine-Midazolam-Propofol Anesthesia in Horses

Clinical Observations during Induction and Recovery of Xylazine-Midazolam-Propofol Anesthesia in Horses

Does Ketamine-Mediated N-methyl-D-aspartate Receptor Antagonism Cause Schizophrenia-like Oculomotor Abnormalities?

A comparison of the predictive performance of three pharmacokinetic models for propofol using measured values obtained during target‐controlled infusion

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