A retrospective cohort study aims at assessing the effectiveness of total knee arthroplasty (TKA) in treating pre-operative aberrant posture in a patient with Knee-hip-spine syndrome. Preoperative and post-operative at (6 and 12 months) assessments, were done by combining clinical evaluations, radiographic analyses, and posture assessments, KSS, HOOS and ODI were used to conduct a thorough analysis of a cohort of 62 patients receiving TKA for KHSS. The main goal was to assess how TKA affected individuals who already had aberrant posture in terms of knee, hip, and spine alignment. Our findings showed that after TKA, pre-operative aberrant posture significantly improved in a way that was clinically meaningful. Significant realignment of the knee, hip, and spine was shown by radiographic data, demonstrating the TKA's all-encompassing remedial effect on the musculoskeletal system. Clinical evaluations correlated to the radiological results, with patients expressing better functional results and more effective postoperative pain alleviation which were demonstrated by the HOOS, KSS and ODI scores. The research highlights the advantages of TKA that extend beyond the knee joint by indicating a favourable link between patient-reported improvements and the treatment of aberrant posture. Our study concluded that, in the treatment of knee osteoarthritis, hip dysfunction, and spinal problems, TKA significantly improves preoperative aberrant posture in patients with KHSS. Following total knee arthroplasty (TKA), the realignment of the lower limbs has a role in improving the balance of the spine, which in turn reduces disability and improves the quality of life for patients. The best surgical methods and post-operative care plans must be determined via more study in order to optimize the advantages of TKA for patients with KHSS.