Total Magnesium Intake and Colorectal Cancer Incidence in Women

Cook, Nancy R.; Lee, I-Min; Manson, JoAnn E.; Buring, Julie E.; Zhang, Shumin M.

doi:10.1158/1055-9965.epi-06-0454

Cited by 26 publications

(35 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For site-specific cancer 21 incidence, our result supports the finding of a Dutch cohort study that dietary magnesium 22 intake was not associated with colorectal cancer risk (33). Other three prospective cohortstudies of women reported either a significantly inverse association or a null association 1 (30)(31)(32). The average energy-adjusted dietary magnesium intake of these women cohorts 2 were 289, 232, and 329 mg/d, respectively, comparable to that of our female sub-cohort 3 (288 mg/d).…”

Section: Dietary Magnesium Intake 18supporting

confidence: 59%

“…7 8 Magnesium is another important mineral with various metabolic and physiological 9 functions that influence carcinogenesis (22)(23)(24). Although animal studies have 10 consistently suggested an inhibitory effect of dietary magnesium intake on colorectal 11 cancer risk (25)(26)(27)(28)(29), available epidemiological findings are few and far from being 12 conclusive (30)(31)(32)(33). Relationships between dietary magnesium intake and the risks of 13 other common site-specific cancers have been scarcely reported in literatures.…”

Section: Introduction 23mentioning

confidence: 99%

See 1 more Smart Citation

Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg)

Kaaks

Linseisen

et al. 2011

Cancer Causes Control

View full text Add to dashboard Cite

To prospectively evaluate the associations of dietary calcium and magnesium intake with cancer incidence and mortality, data of 24,323 participants of the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg), who were aged 35-64 years and cancer-free at recruitment (1994)(1995)(1996)(1997)(1998), were analyzed using multivariate Cox regression models. After an average follow-up time of 11 years, 2,050 incident cancers were diagnosed and 513 cancer deaths occurred. Dietary calcium intake was inversely but not statistically significantly associated with colorectal cancer risk (hazard ratio [HR] for per 100 mg increase in intake: 0.95; 95% confidence interval [CI]: 0.88, 1.02) and lung cancer risk (HR for per 100 mg increase in intake: 0.94; 95% CI: 0.87, 1.02). No statistically significant associations were observed between dietary calcium intake and site-specific or overall cancer incidence or mortality. Dietary magnesium intake was not statistically significantly associated with any of the investigated outcomes. This prospective cohort study provides no strong evidence to support that high dietary calcium and magnesium intake in the intake range observed in a German population may reduce cancer incidence or mortality. To prospectively evaluate the association of dietary calcium and magnesium intake with 2 cancer incidence and mortality and all-cause mortality, the authors analyzed data of 3 24,323 participants of the Heidelberg cohort of the European Prospective Investigation 4 into Cancer and Nutrition (EPIC-Heidelberg), who were aged 35-64 years and cancer-5 free at recruitment stage (1994)(1995)(1996)(1997)(1998), using multivariate Cox regression models. After an 6 average follow-up time of 11 years, 2,050 incident cancers were diagnosed and 513 7 cancer deaths occurred (all-cause deaths = 1,161). Dietary calcium intake was inversely 8 but not statistically significantly associated with colorectal cancer risk (hazard ratio (HR) 9for per 100-mg increase of intake: 0.95; 95% confidence interval (CI): 0.88, 1.02) and 10 lung cancer risk (HR for per 100-mg increase of intake: 0.94; 95% CI: 0.87, 1.02). No 11 statistically significant association was observed between dietary calcium intake and total 12 cancer incidence. Compared with participants in the lowest quartile of dietary calcium 13 intake, participants in the highest quartile had an increased risk of all-cause mortality (HR: 14 1.20; 95% CI: 0.99, 1.45; P trend = 0.09; HR for per 100-mg increase of intake: 1.02; 95% 15 CI: 1.00, 1.05). Dietary magnesium intake was not statistically significantly related to 16 any of the investigated outcomes. This prospective cohort study provides no strong 17 evidence to support the preventive effect of dietary calcium and magnesium intake on 18 cancer incidence and mortality. However, this study suggests a mild adverse effect of 19 dietary calcium intake on all-cause mortality. 20 21

show abstract

Section: Dietary Magnesium Intake 18supporting

confidence: 59%

Section: Introduction 23mentioning

confidence: 99%

Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg)

Kaaks

Linseisen

et al. 2011

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…Ein Review und das Cochrane-Review [75,76] fassen zusammen, dass die meisten der bisher veröffentlich-ten Studien von unzureichender Qualität sind. Die wenigen methodisch gut durchgeführten Studien zeigen keine positiven Effekte auf das Überleben bei verschiedenen Tumorarten.…”

Section: Komplementäre Und Alternative Medizinunclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

151

View full text Add to dashboard Cite

“…[19][20][21][22][23][24][25][26] The purpose of this study was to examine the relationship between magnesium intake and the risk of CRC by undertaking a metaanalysis of prospective studies. We attempted to plan, conduct and report this meta-analysis in adherence to the guidelines of the 'Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group'.…”

Section: Introductionmentioning

confidence: 99%

Magnesium intake and risk of colorectal cancer: a meta-analysis of prospective studies

Pang

2012

Eur J Clin Nutr

View full text Add to dashboard Cite

Epidemiologic studies have suggested that magnesium intake may be associated with a decreased risk of colorectal cancer (CRC), but the findings have been inconsistent. We aimed to assess this association by conducting a meta-analysis of prospective studies. We performed a literature search on PubMed database through July 2012 to identify prospective studies of magnesium intake in relation to CRC risk. Reference lists of the retrieved articles were also reviewed. A random-effects model was used to compute the summary risk estimates. Eight prospective studies containing 338 979 participants and 8000 CRC cases met the inclusion criteria. The summary relative risk (RR) for the highest vs lowest category of magnesium intake for CRC was 0.89 (95% CI, 0.79-1.00), with little evidence of heterogeneity. Restricting the analysis to six studies that have adjusted for calcium intake yielded a similar result. For colon and rectal cancer, the pooled RR was 0.81 (95% CI, 0.70-0.93) and 0.94 (95% CI, 0.72-1.24), respectively. In the doseresponse analyses, the summary RRs for an increment of magnesium intake of 50 mg/day for colorectal, colon and rectal cancer were, respectively, 0.95 (95% CI, 0.89-1.00), 0.93 (95% CI, 0.88-0.99) and 0.93 (95% CI, 0.83-1.04), and there was some evidence of heterogeneity; omitting one study that substantially contributed to the heterogeneity yielded generally similar results, but with low heterogeneity. We detected no indication of publication bias. On the basis of the findings of this meta-analysis, a higher magnesium intake seems to be associated with a modest reduction in the risk of CRC, in particular, colon cancer.

show abstract

Total Magnesium Intake and Colorectal Cancer Incidence in Women

Cited by 26 publications

References 26 publications

Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg)

Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg)

S3-Leitlinie – Kolorektales Karzinom

Magnesium intake and risk of colorectal cancer: a meta-analysis of prospective studies

Contact Info

Product

Resources

About