Total Microfluidic chip for Multiplexed diagnostics (ToMMx)

Özen, Mehmet Özgün; Sridhar, Kaushik; Ogut, Mehmet Giray; Shanmugam, Akash; Avadhani, Anirudh; Kobayashi, Yukari; Wu, Joseph C.; Haddad, François; Demirci, Utkan

doi:10.1016/j.bios.2019.111930

Cited by 16 publications

(11 citation statements)

References 32 publications

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“…However, the main challenge that these applications face is the ability to preserve the specimen and avoid contamination. Moreover, motile micro/nanorobots could be used to collect diverse biomarkers, such as exosomes [264][265][266] (small vesicles excreted from cells) and disease markers. [267,268]…”

Section: Biopsy/sample Collectionmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical imaging are discussed. The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings. Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.

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Section: Biopsy/sample Collectionmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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“…In general medical practice, multiplexed testing is used for identifying inflammatory markers [ 105 , 106 ]. MIA devices adapted for POC diagnostics can be useful to detect several respiratory viruses from a single nasopharyngeal swab sample [ 211 ]. Detection of ions of heavy metals (e.g., Hg 2+ , Pb 2+ , Ag + , or Cr 3+ ) and S 2− , which are responsible for diseases, is another application of MIAs [ 111 ].…”

Section: Spot Tests In Practice: Past and Present Of This Classical Methodsmentioning

confidence: 99%

Spot tests: past and present

Doménech‐Carbó

2021

ChemTexts

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Graphic abstract Microchemistry, i.e., the chemistry performed at the scale of a microgram or less, has its roots in the late eighteenth and early nineteenth centuries. In the first half of the twentieth century a wide range of spot tests have been developed. For didactic reasons, they are still part of the curriculum of chemistry students. However, they are even highly important for applied analyses in conservation of cultural heritage, food science, forensic science, clinical and pharmacological sciences, geochemistry, and environmental sciences. Modern pregnancy tests, virus tests, etc. are the most recent examples of sophisticated spot tests. The present ChemTexts contribution aims to provide an overview of the past and present of this analytical methodology.

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“…Recent advances have opened new avenues for on-chip ELISA systems, which can significantly lower the required assay time and sample volume using antibody-functionalized magnetic beads (figure 2(b)) [21,41,42]. These particles are mixed with biofluid and then bind to their specific targets; thus, enabling the recovery and collection of biomarkers using a permanent magnet [43,44]. Advances in micro-robotics consisting of micro/nanostructures capable of converting local or external energy into mechanical energy and locomotion [45][46][47] have been used as 'on-the-fly' capture and isolation platforms of various biomarkers, including nucleic acid, proteins, and cancer cells from complex samples [48,49].…”

Section: Biochemical Enrichment Of Biomarkersmentioning

confidence: 99%

Progress and challenges in biomarker enrichment for cancer early detection

et al. 2021

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Cancer cells generate and secrete diverse molecules into circulation that could be used as signatures for health and disease. A significant obstacle in detecting such molecules derives from their low signal-to-noise ratio in subsequent downstream analyses. Developing reliable tools and methods for cancer early detection is crucial for advancing global strategies to decrease mortality, monitor disease progression and therapy, and improve the quality of life of patients. This perspective critically addresses recent developments in cancer early detection, highlighting current trends in the enrichment of cancer-related biomarkers, dividing them into biochemical and biophysical methods. Finally, we provide insights into the challenges and opportunities in biomarker isolation and enrichment protocols. Integrating these methods into clinical decision-making pipelines could lead to a better understanding of cancer progression, treatment efficacy, and hence improving the medical outcomes for cancer patients.

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Total Microfluidic chip for Multiplexed diagnostics (ToMMx)

Cited by 16 publications

References 32 publications

Medical Micro/Nanorobots in Precision Medicine

Medical Micro/Nanorobots in Precision Medicine

Spot tests: past and present

Progress and challenges in biomarker enrichment for cancer early detection

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