Total nutritional manipulation in humans: report of acancer patient

Bozzetti, Federico; Cozzaglio, Luca; Gavazzi, Cecilia; Brandi, Sergio; Bonfanti, G.; Lattarulo, Michele; Gennari, Leandro

doi:10.1016/s0261-5614(96)80243-3

Cited by 18 publications

(10 citation statements)

References 21 publications

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“…Such a metabolic discrepancy is in agreement with experimental data in tumour-bearing animals [60e62] and would explain the benefits reported in the preliminary publications by Safdie et al [130] and Cheng et al [104] in fasting (hyperketonemic) patients during chemotherapy (so-called differential stress resistance). However a phase I-II trial launched by the Norris University of South California (Short-Term Fasting Prior to Platinum-Based Chemotherapy: Feasibility and Impact on Toxicity) to validate such hypothesis, is still accruing patients and no preliminary results have been published.…”

Section: Resultssupporting

confidence: 88%

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Toward a cancer-specific diet

Bozzetti

Zupec‐Kania²

2016

Clinical Nutrition

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Section: Resultssupporting

confidence: 88%

“…Only two studies [129,130] used a normocaloric regimen, whereas the remaining ones [100,131e134] adopted a regimen of more or less marked CR. Taken all together these results would show that in cancer patients CR or KD are feasible and safe even for a long time and KD is well accepted and tolerated.…”

Section: Clinical Experience In Humansmentioning

confidence: 99%

Toward a cancer-specific diet

Bozzetti

Zupec‐Kania²

2016

Clinical Nutrition

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“…Reported adverse events included: CTCAE grade 1–2: Constipation, diarrhea, nausea and vomiting 1 patient experienced DLT (dehydration grade 3) 3. Average weight loss: 8.2 kg Bozzetti et al [ 48 ] Single case report N = 1 Desmoid tumor 28y TPN consisting of 28 kcal fat/kg body weight/day, 1.5 g protein/kg body weight/day; 40 g glucose/day Duration: 5 months 1. bodyweight 2. adverse events 1. Body weight increased by 1 kg (from 61 to 62 kg) 2.…”

Section: Resultsmentioning

confidence: 99%

The use of ketogenic diets in cancer patients: a systematic review

2021

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Ketogenic diets are a widely known, yet controversial treatment for cancer patients. In this review, we summarize the clinical evidence for anti-tumor effects, as well as the effects on anthropometry, quality of life, adverse events and adherence in cancer patients. In April 2019, a systematic search was conducted searching five electronic databases (EMBASE, Cochrane, PsychInfo, CINAHL and Medline) to find studies analyzing the use, effectiveness and potential harm of a ketogenic diet in cancer patients of any age as sole or complementary therapy. From all 19.211 search results, 46 publications concerning 39 studies with 770 patients were included in this systematic review. The therapy concepts included all forms of diets with reduced carbohydrate intake, that aimed to achieve ketosis for patients with different types of cancer. Most studies had a low quality, high risk of bias and were highly heterogeneous. There was no conclusive evidence for anti-tumor effects or improved OS. The majority of patients had significant weight loss and mild to moderate side effects. Adherence to the diet was rather low in most studies. Due to the very heterogeneous results and methodological limitations of the included studies, clinical evidence for the effectiveness of ketogenic diets in cancer patients is still lacking.

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“…We tried this approach in a patient receiving lipid TPN, with encouraging results in tolerance and feasibility [50].…”

Section: Parametermentioning

confidence: 99%

Artificial Nutrition in Cancer Patients: Which Route, What Composition?

et al. 1999

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The state of art of artificial nutrition in depleted cancer patients is reviewed in brief. Because cancer cachexia cannot be equated to simple nutrient deficiency but is due instead to complex metabolic abnormalities, the nutritional effects of total parenteral (TPN) and enteral (EN) nutrition are more limited than in starving subjects. TPN and EN usually prevent further deterioration of the nutritional status, although they are not able to fully reverse a state of depletion. There is evidence that quantitative and qualitative modulation of certain nutrients may obtain better results because of a favorable impact on host metabolism. Research in this field is fully warranted. Moreover, the effects of some substrates on tumor metabolism and tumor growth require further investigation to define a nutritional regimen able to maintain the host metabolism with minimum stimulation of tumor growth.

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Total nutritional manipulation in humans: report of acancer patient

Cited by 18 publications

References 21 publications

Toward a cancer-specific diet

Toward a cancer-specific diet

The use of ketogenic diets in cancer patients: a systematic review

Artificial Nutrition in Cancer Patients: Which Route, What Composition?

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