Total Oxidant Status and Bone Resorption Biomarkers in Serum and Gingival Crevicular Fluid of Patients With Periodontitis

Abstract

The present results reveal that TOS, RANKL, and RANKL/OPG values are systemically and locally increased in periodontitis and that this increase is more evident in AgP than CP. These findings further suggest that oxidative stress is closely associated with the severity of periodontitis and bone resorption biomarkers.

Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis

“…The systemically healthy subjects with periodontitis (group B) exhibited lower OPG levels in GCF when compared with periodontally healthy subjects (group D), in accordance with the results of previous studies (9,(29)(30)(31). RANKL levels in GCF were not statistically different from the periodontally healthy groups, contrarily to some reports (9,29,31), although in accordance with the results of a recent study, which demonstrated no significiant difference in GCF concentrations of sRANKL and OPG (32).…”

“…RANKL levels in GCF were not statistically different from the periodontally healthy groups, contrarily to some reports (9,29,31), although in accordance with the results of a recent study, which demonstrated no significiant difference in GCF concentrations of sRANKL and OPG (32).…”

“…GCF concentration of OPG was lower in chronic periodontitis, but increased after periodontal phase I therapy, although not significantly (31). The RANKL/OPG ratio was also reported unchanged at 2, 3, and 4 months after periodontal therapy (33,34).…”

Assessment of Lipid Peroxidation Levels and Total Antioxidant Status in Chronic and Aggressive Periodontitis Patients: An in vivo Study

“…Similar results were reported in the past literature. 18 Baltacıoğlu et al 19 investigated the correlation between the TOS and receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) levels in CP and GP patients. They assessed 30 GP patients, 30 CP patients, and 28 healthy controls.…”

Gingival crevicular fluid oxidative stress level in patients with periodontal disease and hyperlipidemia

“…1 Oxidative stress (OS) promotes the pathophysiological progression of periodontal disease by triggering local and systemic inflammatory responses. 2,3,4,5 Hyperlipidemia, i.e., elevated serum lipid levels, is thought to cause imbalance in the production of highly reactive molecular species and antioxidant defenses, leading to increased OS and creating a proinflammatory state that predisposes subjects to infections. 1,6 Hyperlipidemia is a risk factor for atherosclerotic diseases by causing hyperactivity of white blood cells, 7 and this hyperactivity leads to an increase in production of reactive oxygen species (ROS) and lipid peroxidation.…”