Total Pancreatectomy for Carcinoma of the Pancreas in a Diabetic Person

Dixon, Claude F.; Comfort, Mandred W.; Lichtman, AH; Benson, Raymond E.

doi:10.1001/archsurg.1946.01230050628001

Cited by 33 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pancreatectomised subjects continue to suffer from the symptoms of poor diabetic control since they are particularly at risk from hypoglycaemia [18]. In addition, diabetic ketoacidosis has been reported in these patients [7,8] demonstrating that hyperglycaemia and hyperketonaemia can still occur in situations of inadequate insulin replacement.…”

Section: Discussionmentioning

confidence: 99%

Persistent metabolic abnormalities in diabetes in the absence of glucagon

et al. 1977

View full text Add to dashboard Cite

In order to investigate the contribution of glucagon to the abnormalities of carbohydrate and lipid metabolism in diabetes, hormones and metabolites were measured in response to IV arginine in 5 juvenile onset (control) diabetics and 5 totally pancreatectomised subjects. In the basal state, both control diabetics and pancreatectomised patients showed abnormally elevated levels of plasma glucose, blood 3-hydroxybutyrate, glycerol and plasma free fatty acids (NEFA), although no glucagon was detectable in the plasma of the pancreatectomised subjects. Blood concentrations of the gluconeogenic precursors alanine and glycerol were higher pancreatectomised patients than in the diabetics. Following infusion of arginine, the rise in glucagon observed in the diabetics was accompanied by a significant increase in plasma glucose and a fall in blood lactate when compared to the pancreatectomised subjects. In spite of the rise in glucagon in the control diabetics, no sigficant change was found in the concentrations of ketone bodies, glycerol or NEFA. Thus glucagon does not seem to have a primary role in producing the metabolic abnormalities of diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Persistent metabolic abnormalities in diabetes in the absence of glucagon

et al. 1977

View full text Add to dashboard Cite

show abstract

“…Dixon et al (155) have described a case of total pancreatectomy in man for the treatment of carcinoma; postoperatively, there was fecal wastage of about half the ingested fat and a third of the pro tein, but no significant loss of calcium and phosphorus. The daily administration of 15 gm.…”

Section: Pancreasmentioning

confidence: 99%