Total pancreatectomy in dogs

Cobb, Luther F.; Merrell, Ronald C.

doi:10.1016/0022-4804(84)90184-7

Cited by 32 publications

(6 citation statements)

References 14 publications

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“…Experimental studies in dogs undergoing total pancreatectomy without duodenectomy revealed that the recurrent duodenal branch is consistently present and provides sufficient blood supply to the duodenum, even if the pancreaticoduodenal arcade is resected in its entirety. 18 In the dog in our report, the large mesenteric rent could not be re-apposed during surgery and was left open as previously mentioned. Open mesenteric rents, omental rents, as well as partial ruptures of the duodenocolic ligament, pose a theoretical risk of small intestinal or colonic entrapment.…”

Section: Discussionmentioning

confidence: 53%

“…A more likely alternative explanation is that sufficient blood supply might have been available regardless of the development of collateral blood supply, due to contribution from the recurrent duodenal branch of the right gastroepiploic artery. Experimental studies in dogs undergoing total pancreatectomy without duodenectomy revealed that the recurrent duodenal branch is consistently present and provides sufficient blood supply to the duodenum, even if the pancreaticoduodenal arcade is resected in its entirety 18 …”

Section: Discussionmentioning

confidence: 99%

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Partial pancreatectomy and en bloc excision of thrombosed vessels in a dog with insulinoma of the right limb of the pancreas

Valls

Cantatore²

2022

Vet Record Case Reports

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A 7‐year‐old, neutered golden retriever was evaluated for acute episodes of weakness, ataxia and disorientation, low blood glucose and inappropriately high insulin levels. Results of computed tomography revealed irregular enlargement of the distal tip of the right pancreas associated with thrombosis of the pancreaticoduodenal and first jejunal vein. A partial pancreatectomy with en bloc excision of the thrombosed vessels was performed. The distal duodenum and proximal jejunum maintained normal peristalsis and remained viable, obviating the need for concurrent intestinal resection and anastomosis. Histopathology confirmed a completely excised insulinoma with an associated tumour thrombus (vascular invasion of tumour). The dog remains alive with no evidence of recurrence 18 months after surgery.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Partial pancreatectomy and en bloc excision of thrombosed vessels in a dog with insulinoma of the right limb of the pancreas

Valls

Cantatore²

2022

Vet Record Case Reports

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“…In the control group (A), the animals were not operated on and demonstrated normal fasting glucose values, fasting insulin and intravenous glucose tolerance tests (IGTT). In the other groups, all the animals underwent total pancreatectomy without duodenectomy 11 . In group B, the animals underwent only a total pancreatectomy; in group C, the animals also underwent the autotransplant of pancreatic islet tissue in the spleen; in group D, the animals were submitted to allograft of pancreatic islet tissue in the spleen without immunosuppression, and in group E, the allograft of pancreatic islet tissue in the spleen was done with immunosuppression.…”

Section: Methodsmentioning

confidence: 99%

Pancreatic islet allograft in spleen with immunossuppression with cyclosporine. Experimental model in dogs

et al. 2011

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PURPOSE: To study the functional behavior of the allograft with immunosuppression of pancreatic islets in the spleen. METHODS: Five groups of 10 Mongrel dogs were used: Group A (control) underwent biochemical tests; Group B underwent total pancreatectomy; Group C underwent total pancreatectomy and pancreatic islet autotransplant in the spleen; Group D underwent pancreatic islet allograft in the spleen without immunosuppressive therapy; Group E underwent pancreatic islet allograft in the spleen and immunosuppression with cyclosporine. All of the animals with grafts received pancreatic islets prepared by the mechanical-enzymatic method - stationary collagenase digestion and purification with dextran discontinuous density gradient, implanted in the spleen. RESULTS: The animals with autotransplant and those with allografts with immunosuppression that became normoglycemic showed altered results of intravenous tolerance glucose (p < 0.001) and peripheral and splenic vein plasmatic insulin levels were significantly lower (p < 0.001) in animals that had allografts with immunosuppression than in those with just autotransplants. CONCLUSIONS: In the animals with immunosupression with cyclosporine subjected to allograft of pancreatic islets prepared with the mechanical-enzymatic preparation method (stationary collagenase digestion and purification with dextran discontinuous density gradient), the production of insulin is decreased and the response to intravenous glucose is altered.

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“…N.J.) and 0.5 mg/kg Anectine (Burroughs Welcome, Research Triangle Park, N.C.). Total pan createctomy is performed via a midline laparotomy, according to the method described by Cobb and Merrell [8], After separate cannulation of the ducts of the right limb and that of the combined body and left limb, the pancreas is transsected at the ductal bifurca tion and both parts are stored in cold Hanks' balanced salt solution (HBSS).…”

Section: Pancreatectomymentioning

confidence: 99%

Canine Pancreatic Islet Transplantation: A Comparison of Two Isolation Techniques

et al. 1990

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A new method (type B) for isolation of canine islets was developed, utilizing intraductal collagenase perfusion, stationary digestion, filtration and tissue separation by means of a dextran density gradient. The results of this technique were compared with those of a previously established method (type A). Islets were autotransplanted either via the splenic or the portal vein. Lasting normoglycemia was obtained in 5/8 intrasplenic type B transplants (63%), 6/8 intrahepatic type B transplants (75%), 5/6 intrasplenic type A transplants (83%) and 0/3 intrahepatic type A transplants. No difference was found in metabolic parameters 2 weeks after successful transplantation following type A or B islet isolation. Islet yield was higher with type A and purification better with type B isolation. Both techniques are relatively simple and inexpensive. Because of its higher purification rate and the success of intrahepatic islet transplantation method B has replaced method A as the routine procedure in our laboratory.

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Total pancreatectomy in dogs

Cited by 32 publications

References 14 publications

Partial pancreatectomy and en bloc excision of thrombosed vessels in a dog with insulinoma of the right limb of the pancreas

Partial pancreatectomy and en bloc excision of thrombosed vessels in a dog with insulinoma of the right limb of the pancreas

Pancreatic islet allograft in spleen with immunossuppression with cyclosporine. Experimental model in dogs

Canine Pancreatic Islet Transplantation: A Comparison of Two Isolation Techniques

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