Total Parenteral Nutrition Decreases Liver Oxidative Metabolism and Antioxidant Defenses in Healthy Rats: Comparative Effect of Dietary Olive and Soybean Oil

Lespine, Anne; Fernandez, Yvette; Périquet, B.; Galinier, Anne; García, Jesús Felicidades; Anglade, F.; Ghisolfi, J; Thouvenot, J

doi:10.1177/014860710102500252

Cited by 11 publications

(16 citation statements)

References 36 publications

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“…Complications of TPN include immune and hepatic dysfunction and animal studies have sought to identify whether ClinOleic offers benefit over other lipid emulsions with respect to these complications (Table 2) [28][29][30][31][32]. Moussa et al [28] evaluated lymphocyte activation in rats that had received either a soybean oil-based emulsion (Ivelip; Baxter, Maurepas, France) or ClinOleic for 6 h. There was no statistically significant difference in spleen lymphocyte subsets or proliferation between the two groups of rats.…”

Section: Animal Studiesmentioning

confidence: 99%

“…Lespine et al [29] investigated the effects of soybean oil (Ivelip) versus ClinOleic on hepatic Olive oil in parenteral nutrition Sala-Vila et al 167…”

Section: Animal Studiesmentioning

confidence: 99%

“…168 Lipid metabolism and therapy [28] ClinOleic versus Ivelip; 6 days; rats 1) Fatty acid composition of spleen lymphocytes phospholipids 1) ClinOleic: " oleic acid and # linoleic, dihomo-g-linolenic and docosapentaenoic acids 2) Spleen lymphocyte subsets 2) None 3) Spleen T lymphocyte proliferation 3) None 4) Expression of IL-2 receptor a-chain on spleen lymphocytes 4) ClinOleic: " [29] ClinOleic versus Ivelip; 6 days; rats. High supplies of PUFA are also associated to an increased risk of membrane peroxidation, which can worsen the oxidative stress of premature infants [43].…”

Section: Paediatric Applicationsmentioning

confidence: 99%

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Olive oil in parenteral nutrition

Sala‐Vila

Barbosa

Calder

2007

Current Opinion in Clinical Nutrition and Metabolic Care

103

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ClinOleic is safe and well tolerated in preterm infants, and in home parenteral nutrition, haemodialysis, trauma and burn patients and may offer advantages with regard to liver function, oxidative stress and immune function. ClinOleic may offer significant advantage over soybean oil-based emulsions in terms of glucose metabolism in preterm infants. More clinical studies of ClinOleic are required and these should include evaluation of oxidative stress markers and immune function as well as of clinical outcomes.

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Section: Animal Studiesmentioning

confidence: 99%

“…Lespine et al [29] investigated the effects of soybean oil (Ivelip) versus ClinOleic on hepatic Olive oil in parenteral nutrition Sala-Vila et al 167…”

Section: Animal Studiesmentioning

confidence: 99%

Section: Paediatric Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Olive oil in parenteral nutrition

Sala‐Vila

Barbosa

Calder

2007

Current Opinion in Clinical Nutrition and Metabolic Care

103

View full text Add to dashboard Cite

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“…Antioxidant properties of olive oil, originating from its natural components, have been known for a long time, and synergism between these antioxidants may have an increased effect [12][13][14]. In this respect, synergistic interactions have been postulated and described for ß-carotene and ·-tocopherol, two lipid-soluble antioxidants present in olive oil which may function at different localizations in biological membranes [36].…”

Section: Discussionmentioning

confidence: 99%

“…Their oleic acid content allows to modulate the soybean oil composition and to elaborate lipid blends with fatty acid families (monounsaturated: oleic acid; polyunsaturated ˆ-6: linoleic acid; polyunsaturated ˆ-3: ·-linolenic acid). A comparable energy source with a limited risk of in vitro and in vivo peroxidation due to the high levels of monounsaturates [10,11] and an increased content of natural antioxidants are among the main advantages of olive oil over soybean oil emulsions [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Use of Olive Oil Based Emulsions as an Alternative to Soybean Oil Based Emulsions in Total Parenteral Nutrition and Their Effects on Liver Regeneration following Hepatic Resection in Rats

Ok¹,

Yılmaz²,

Karaküçük³

et al. 2003

Ann Nutr Metab

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Background/Aim: The main objective of this study was to compare the effects of olive oil to those of soybean oil on liver tissue regeneration following hepatic resection in rats. Methods: Seventy albino Wistar rats were randomly assigned to seven groups which contained 10 rats each. Group 1 was the sham-treated group; groups 2 and 3 received total parenteral nutrition (TPN) containing soybean oil lipid emulsions (20% Lipofundin MCT/LCT) for 48 or 72 h; groups 4 and 5 received TPN containing olive oil (80%)/soybean oil (20%) lipid emulsions (ClinOleic 20%) for 48 or 72 h; group 6 was the control group for 48 h, and group 7 was the control group for 72 h. TPN was given via internal jugular vein, and 70% hepatic resection was performed in the study groups. In addition, hepatic resections with no TPN were performed in the control groups, except the sham group. Relative liver weight, mitotic index, proliferating cell nuclear antigen labeling index, and carnitine levels in liver tissue samples were used to assess hepatic regeneration. Thiobarbituric acid reactive substances were measured as an index of lipid peroxidation and oxidative tissue damage. Alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were parameters for the liver function. Results: The relative liver weight increased significantly with minimal hepatosteatosis in the olive oil treated groups. Lipid peroxidation significantly decreased with near-normal serum levels of the liver function parameters in the olive oil/soybean oil treated groups, and mitotic index and proliferating cell nuclear antigen labeling index reached their maximum level in rats receiving TPN containing any kind of lipid emulsions for 48 h following resection. Conclusions: The use of olive oil/soybean oil lipid emulsions in TPN has important beneficial effects on the liver regeneration, and the antioxidant properties of olive oil originating from its natural components indirectly contribute to the liver regeneration in rats.

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Effect of a parenteral fish‐oil‐containing lipid emulsion on liver lipid perioxidation and antioxidative defenses in Lewis rats

Filho

Torrinhas

Tesser

et al. 2023

J Parenter Enteral Nutr

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Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), naturally abundant in fish oil (FO), are known for their anti-inflammatory and potential antioxidant properties. The aim in this article is to evaluate the effect of the infusion of a parenteral FO-containing lipid emulsion on markers of liver lipid peroxidation and oxidative stress in rats undergoing central venous catheterization (CVC). Methods: After 5-day acclimatization, adult Lewis rats (n = 42) receiving a 20-g/day AIN-93M oral diet were randomly subdivided into four groups: (1) basal control (BC) (n = 6), without CVC or LE infusion; (2) SHAM (n = 12), with CVC but without LE infusion; (3) soybean oil (SO)/medium-chain triglyceride (MCT) (n = 12), with CVC and receiving LE without FO (4.3 g/kg fat); and (4) SO/MCT/FO (n = 12), with CVC and receiving LE containing 10% FO (4.3 g/kg fat). Animals from the BC group were euthanized immediately after acclimatization. The remaining groups of animals were euthanized after 48 or 72 h of surgical follow-up to assess profiles of liver and plasma fatty acids by gas chromatography, liver gene transcription factor Nrf2, F2isoprostane lipid peroxidation biomarker, and the antioxidant enzymes glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) by enzyme-linked immunosorbent assay. R program (version 3.2.2) was utilized for data analysis.Results: Compared with the other groups, liver EPA and DHA levels were higher in the SO/MCT/FO group, which also showed the highest liver Nrf2, GPx, SOD, and CAT levels and lower liver F2-isoprostane (P < 0.05). Conclusion:Experimental delivery of FO via EPA and DHA sources in a parenteral LE was associated with a liver antioxidant effect.

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Total Parenteral Nutrition Decreases Liver Oxidative Metabolism and Antioxidant Defenses in Healthy Rats: Comparative Effect of Dietary Olive and Soybean Oil

Abstract: In rats, TPN decreased the liver oxidative metabolism and enzymatic antioxidant defenses. This may be related to saturation of the liver microsomal fatty acids.

Cited by 11 publications

References 36 publications

Olive oil in parenteral nutrition

Olive oil in parenteral nutrition

Use of Olive Oil Based Emulsions as an Alternative to Soybean Oil Based Emulsions in Total Parenteral Nutrition and Their Effects on Liver Regeneration following Hepatic Resection in Rats

Effect of a parenteral fish‐oil‐containing lipid emulsion on liver lipid perioxidation and antioxidative defenses in Lewis rats

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