Total phenolic compounds, antioxidant potential and α-glucosidase inhibition by Tunisian Euphorbia paralias L.

Hlila, Malek Besbes; Majouli, Kaouther; Harzallah‐Skhiri, Fethia; Jannet, Hichem Ben; Aouni, Mahjoub; Mastouri, Maha; Selmi, Boulbaba

doi:10.12980/jclm.4.2016j6-118

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Luteolin (30) exhibits a similar inhibition profile on both enzymes but to a lesser extent of consent on αglucosidase. 18 out of 31 recorded findings 65,88,110,111,113,116,117,119,122,123,[126][127][128][129][130][131][132][133] showed stronger activity on α-glucosidase than acarbose, in contrast with the remaining 13 studies, 33,35,51,79,106,108,112,115,[134][135][136][137][138] making a 6:4 conflict. There was greater unity in the results of α-amylase inhibition, confirming a moderate but generally weaker activity than acarbose on α-amylase (IC50 ranging from 14.57 µM to 1 mM).…”

Section: Flavonesmentioning

confidence: 99%

“…The next ten compounds (52)(53)(54)(55)(56)(57)(58)(59)(60)(61) of this subclass feature flavone glycosides, most commonly glycosylated at the R7 oxygen. Of these glycosides, luteolin-7-O-β-D-glucoside ( 56) is the most well-researched with five studies, 33,113,122,133,162 outlining a comparable activity to acarbose on α-glucosidase and a weaker inhibition on α-amylase. 162 Relatedly, luteolin-7-O-β-D-glucuronide (55) and diosmin (57) all displayed equivalent profiles to acarbose on both enzymes.…”

Section: Flavonesmentioning

confidence: 99%

See 1 more Smart Citation

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2023

Preprint

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Diabetes mellitus remains a major global health burden and great attention is directed at natural therapeutics. This systematic review aimed to evaluate the potential of flavonoids as antidiabetic agents through their ability to inhibit α-amylase and α-glucosidase, two key starch digestive enzymes. Six scientific databases were queried up until August 21, 2022, for in vitro studies reporting the IC50 results of purified flavonoids on α-amylase or α-glucosidase, along with the respective data of acarbose control. A total of 339 articles were assessed as eligible and subjected to the data extraction process, resulting in 1643 retrieved flavonoid structures. Chemical structures were then rigorously standardized and curated to 974 unique compounds, in which 177 flavonoids showed both inhibitions against α-amylase and α-glucosidase. Quality assessment was conducted following a modified CONSORT checklist. The structure-activity relationships revealed that a double bond C2=C3 and a keto group C4=O is essential for simultaneous inhibition. The hydroxyl group at C3 is favourable for α-glucosidase inhibition but detrimental to the effect against α-amylase. Further notable features which affect α-glucosidase and α-amylase inhibition were also discussed. Several limitations were considered, including the inconsistency among included studies, language restriction, and the contemporaneity of the review. In conclusion, the systematic review has summarized some crucial findings in the investigation of flavonoids as dual-target inhibitors against α-glucosidase and α-amylase and proposed several orientations for future research.

show abstract

Section: Flavonesmentioning

confidence: 99%

Section: Flavonesmentioning

confidence: 99%

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The next ten compounds (52)(53)(54)(55)(56)(57)(58)(59)(60)(61) of this subclass feature flavone glycosides, most commonly glycosylated at the R7 oxygen. Of these glycosides, luteolin-7-O-β-D-glucoside ( 56) is the most well-researched with five studies, 57,114,123,161,162 outlining a comparable activity to acarbose on α-glucosidase and a weaker inhibition on α-amylase. 161 Relatedly, luteolin-7-O-β-D-glucuronide (55) and diosmin (57) all displayed equivalent profiles to acarbose on both enzymes.…”

Section: Flavonesmentioning

confidence: 99%

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2023

Preprint

View full text Add to dashboard Cite

Diabetes mellitus remains a major global health burden and great attention is directed at natural therapeutics. This systematic review aimed to evaluate the potential of flavonoids as antidiabetic agents through their ability to inhibit α-amylase and α-glucosidase, two key starch digestive enzymes. Six scientific databases were queried up until August 21, 2022, for in vitro studies reporting the IC50 results of purified flavonoids on α-amylase or α-glucosidase, along with the respective data of acarbose control. A total of 339 articles were assessed as eligible and subjected to the data extraction process, resulting in 1643 retrieved structures, 177 compounds of which showed both inhibitions against α-amylase and α-glucosidase. Quality assessment was conducted following a modified CONSORT checklist. The structureactivity relationships revealed that a double bond C2=C3 and a keto group C4=O is essential for simultaneous inhibition. The hydroxyl group at C3 is favourable for α-glucosidase inhibition but detrimental to the effect against α-amylase. Further notable features which affect α-glucosidase and α-amylase inhibition were also discussed. Several limitations were considered, including the inconsistency among included studies, language restriction, and the contemporaneity of the review. In conclusion, the systematic review has summarized some crucial findings in the investigation of flavonoids as dual-target inhibitors against α-glucosidase and α-amylase and proposed several orientations for future research.

show abstract

The combined fermentation of endophytic bacteria in Zizyphus jujuba and high sugar tolerant yeast to promote cAMP content and activity exploration in jujube juice

Wan,

Wang,

Yin

et al. 2024

J Food Sci Technol

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Total phenolic compounds, antioxidant potential and α-glucosidase inhibition by Tunisian Euphorbia paralias L.

Cited by 3 publications

References 26 publications

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

The combined fermentation of endophytic bacteria in Zizyphus jujuba and high sugar tolerant yeast to promote cAMP content and activity exploration in jujube juice

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