Total Phenolic Content, Antioxidant, Cytotoxicity and Hepatoprotective Activities of Aqueous Extract of Channa striatus (Haruan)

Radzak, Hazirah Abdul; Akim, Abdah Md; Sazali, Siti Sarah; Baharum, Zainal; Nata, Dayana Hazwani Mohd Saudi; Jalil, Athirah Abdul; Sumasundram, Tillai Sharimala; Jais, Abdul Manan Mat; Mokhtaruddin, Norhafizah

doi:10.9790/1959-03635259

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…A study done by Susibalan et al (2018) reported that the consumption of 500 mg/day of Channa striatus for six weeks resulted in improvement in nasal blockage, nasal itchiness, eye itchiness, and general symptoms. Channa striatus extract elicited beneficial effects on AR through its anti-inflammatory properties (Abedi et al, 2012) and antioxidant properties (Radzak et al, 2014). This finding is in line with a previous study done by Thien et al (2002), which found that the content of omega-3 fatty acids in the Channa striatus could reduce inflammation of airways and bronchoconstriction.…”

Section: Effects Of Channa Striatus On Human Diseasessupporting

confidence: 89%

In vivo effects of Channa striatus on humans and animals: a systematic review

hadi¹,

Ooi²,

Kadir³

et al. 2021

IFRJ

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Channa striatus contains biochemical components and albumin, which elicit beneficial effects to the consumers. This review aimed to clarify the effects of Channa striatus consumption on humans and animals in in vivo studies. A systematic search in four electronic databases namely ProQuest, EBSCOhost, PubMed, and SpringerLink was performed to choose the studies on Channa striatus as the interventions, and its effects on animals and humans. The intervention involved: (i) Channa striatus with placebo-controlled, (ii) Channa striatus pre-treated and treated with drugs, (iii) Channa striatus with the combination of Chronic Unpredictable Mild Stress (CUMS), and (iv) Channa striatus pre-treated with amino acids and methylene blue. Thirteen animal studies and seven human studies were included in the final analysis. They investigated the effects of Channa striatus on wound healing, anti-depressant-like effects, anti-inflammatory effects, and effects on human diseases. Consumption of Channa striatus supplements was found in seven studies to benefit wound healing processes due to the contents of amino acids and fatty acids found in Channa striatus extract. Two studies were found regarding Channa striatus lipid decreased the corticosterone level and nuclear factor-kappa B, while two studies reported of DHA content in Channa striatus inhibited the production of inflammatory mediators. Channa striatus elicits a positive effect on the wound healing process and enhanced antidepressant-like and anti-inflammatory effects due to its high content of amino acids and fatty acids.

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Section: Effects Of Channa Striatus On Human Diseasessupporting

confidence: 89%

In vivo effects of Channa striatus on humans and animals: a systematic review

hadi¹,

Ooi²,

Kadir³

et al. 2021

IFRJ

View full text Add to dashboard Cite

show abstract

“…When it is reared in a controlled habitat, the parameters of the aquatic environment such as the pH, temperature and water depth should be kept as close to its natural habitat as possible. For its diet, Haruan fish can be fed with a wide range of food products including formulated food [46][47][48].…”

Section: What Is Haruanmentioning

confidence: 99%

“…In recent years, extensive work has been conducted to analyse the antibacterial effects of the mucus of fish species [93][94][95][96][97], including the Channa species. Several research studies [48,[98][99][100][101][102][103][104] were performed over the years to evaluate the antibacterial and antifungal activities of Haruan. Most of the studies [99][100][101][102][103][104] revealed that Haruan displays some antimicrobial activities, except two studies [98,99] which detected negligible inhibitory effects against Staphylococcus aureus and Escherichia coli strains respectively.…”

Section: Antimicrobial Effectsmentioning

confidence: 99%

HaruanExtract (Channa striatus) as an Effective Mediator in Promoting Wound Healing

Musa¹,

Min²

2022

Skin Grafts for Successful Wound Closure

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Wound healing remains a major issue in surgery. None of the existing treatment modalities in caring for wounds can yet claim to be the holy grail of wound management. Channa striatus, locally known in Malaysia as Haruan, is a freshwater air-breathing carnivorous fish that is proven to influence the different phases of wound healing. As a medicinal fish, not only does Haruan have a high content of amino and fatty acids, which are essential in collagen fibre synthesis during wound recovery, it also abounds in arachidonic acid and polyunsaturated fatty acids that promote prostaglandin synthesis, a vital component of the healing process. Moreover, its antinociceptive effects could potentially reduce wound pain, an important factor in wound healing. Proteomic studies show that a quarter of the total protein detected in freeze- and spray-dried C. striatus extract are actin, myosin and tropomyosin – all molecules that play a role in the wound healing process. Proteomic profiling also reveals that Haruan possesses two types of collagen namely collagen type-I and type-II that confer tensile strength during the healing process. It is proven that collagen along with other components of the extracellular matrix form the granulation tissue which, when contracted, closes the wound and concomitantly aligns the collagen fibres in the extracellular matrix. Hence, it is inferred that Haruan promotes the maturation of granulation tissue, thereby expediting the wound healing process itself. Consequently, it could mediate a faster recovery from surgical wound coupled with a lower incidence of wound infection due to an improved and accelerated wound healing process. Additionally, Haruan has demonstrated its ability in promoting angiogenesis and cell proliferation in wound bed preparation for skin grafting. Furthermore, a Haruan aerosol concentrate can act as a wound dressing at the donor site thereby enhancing the healing process while simultaneously exhibiting some antinociceptive properties. Haruan’s exceptional ability in promoting wound healing together with its potential use in skin grafting would be instrumental in the field of surgery. In essence, the cumulated benefits from all the processes involved would translate into a significant reduction of hospitalisation cost; that would immensely benefit not only the patient, but also the government.

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Section: Antimicrobial Effectsmentioning

confidence: 99%

Skin Grafts for Successful Wound Closure

2022

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tal (LTMGH), India, is presently a consultant general surgeon in Mumbai, India. Her areas of interest are burns, non-burn trauma and wounds, and venous diseases. An acknowledged teacher and sought-after speaker, Dr. Gore established the first cadaver skin bank in India. She is an avid researcher and has been the chief investigator for more than twenty-five national and international clinical trials. She has more than seventy-five publications in national and international journals to her credit and has contributed seventeen chapters to various books. She has been honored with several awards, prizes, scholarships, and orations for her contribution to the fields of her special interest. XIII Contents Preface Section 1 Wound Bed PreparationChapter 1 PrefaceWounds are common injuries that almost every human being experiences. They can vary in depth of tissue damage, etiology, location, contamination, lymphovascular integrity, and sensory neural function. They can be associated with diabetes, cardiovascular morbidity, hepatic and/or renal dysfunction, immunological status, malignancy, nutritional deficiencies, and so on. Wound healing is dependent on all these factors and many more.Wounds that are limited to the epidermis and superficial layers of the dermis generally close and heal naturally. We now know the stages in this process and understand the role of multiple mediators, growth factors, cellular contributions, and the interaction between these components. However, there is no method by which we can control or modify this natural process of wound healing.The situation is different when the wound involves full-thickness skin loss with or without loss of subcutaneous and deeper tissue. These wounds cannot achieve closure naturally, as both epidermal and dermal elements are lost. Without intervention, these wounds may remain as chronic, non-healing ulcers or they may close via wound contraction and formation of scar tissue causing functional limitations, deformities, and disfigurement. These scars may be unstable, leading to repeated breakdown, and are likely to develop Marjolin's ulcer, which is most often a squamous cell carcinoma of aggressive nature. Hence, a general recommendation is that wounds that do not close or that are not likely to close within 3-4 weeks of occurrence should be closed surgically with skin grafting or fasciocutaneous or myocutaneous flaps. This book, Skin Grafts for Successful Wound Closure, focuses on various aspects related to free skin grafts; it does not address flaps. Skin autografts are necessary for providing permanent wound closure. While harvesting a split-thickness skin autograft from the appropriate donor area on the body of the patient, the surgeon is creating a partialthickness wound that needs care for healing. Justifying this new wound and the pain and scarring associated with its healing requires a successful skin graft. Optimal preparation of the recipient wound bed is essential for the success of the graft take.Section I, "Wound Bed Preparation," includes three chapters...

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Total Phenolic Content, Antioxidant, Cytotoxicity and Hepatoprotective Activities of Aqueous Extract of Channa striatus (Haruan)

Cited by 4 publications

References 17 publications

In vivo effects of Channa striatus on humans and animals: a systematic review

In vivo effects of Channa striatus on humans and animals: a systematic review

HaruanExtract (Channa striatus) as an Effective Mediator in Promoting Wound Healing

Skin Grafts for Successful Wound Closure

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