Total phenylethanoid glycosides and magnoloside I_afromMagnolia officinalisvar.bilobafruits inhibit ultraviolet B-induced phototoxicity and inflammation through MAPK/NF-κB signaling pathways

Abstract

Magnolia officinalis var. biloba is used as a traditional medicine in China and as a food additive in the United Kingdom and the European Union. In this study, total phenylethanoid glycosides (TPG) and magnoloside I a (MI a ) from M. officinalis var. biloba fruits showed excellent radical scavenging activities and potent inhibition activities against ultraviolet B (UVB)-induced oxidative damage in vitro. In vivo, TPG and MI a inhibited UVBinduced skin phototoxicity in mice upon continuous irradiation for 10 days. Changes in the levels of malondialdehyde, catalase, glutathione peroxidase, superoxide dismutase, and hydroxyproline caused by UVB irradiation were remarkably reversed in a dose-dependent manner after treatment with TPG or MI a .Protein-level analysis further showed that compared with the UVB group, the TPG high-dose group or MI a group significantly down-regulated MAPK/NF-kB signaling pathways. Therefore, TPG and MI a possessed a powerful photoprotective property that can be applied in food and antiphototoxicity formulations.

Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-κB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth

“…MAPKs are a group of signaling proteins that include p38 mitogen-activated protein kinase, c-Jun nh2-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) [37]. MAPKs and phosphorylated MAPK proteins can regulate NF-κB activation [38]. The activation of this signaling pathway is closely related to the development of inflammatory responses [39].…”