Total serum cholesterol levels and suicide attempts in child and adolescent psychiatric inpatients

Plana, Teresa; Gracia, R.; Méndez, Iria; Pintor, Luís; Lázaro, Luisa; Castro‐Fornieles, Josefina

doi:10.1007/s00787-009-0084-x

Cited by 17 publications

(12 citation statements)

References 36 publications

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“…1). Finally, a total of 65 studies met the inclusion criteria and were included in the meta-analysis: 8 cohort studies, 16,[26][27][28][29][30][31][32] 8 case-control studies 13,17,[33][34][35][36][37][38] and 49 cross-sectional studies, 9,10,14,15,18,19, involving 510 392 participants. The participants were categorized as follows: 1) patients with various psychiatric diseases (e.g., depression, schizophrenia, personality disorder, drug and alcohol addictions) with suicidality, who we defined as suicidal patients; 2) patients with various psychiatric diseases without suicidality, who we defined as nonsuicidal patients; and 3) healthy participants without any psychiatric disease and suicidality, who we defined as healthy controls.…”

Section: Search Resultsmentioning

confidence: 99%

Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies

Ding

et al. 2016

jpn

128

111

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Section: Search Resultsmentioning

confidence: 99%

Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies

Ding

et al. 2016

jpn

128

111

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“…In a study of 66 patients ranging from 8 to 18 years consecutively admitted to a psychiatric inpatient unit following attempted suicide, levels of cholesterol were found to be significantly lower in attempted suicide patients than in inpatients who had not attempted suicide. Control subjects were paired with case subjects according to psychiatric diagnosis, age and gender (Plana et al, 2010). In contrast, in a similar study of 152 adolescent psychiatric inpatients ranging from 12 to 21 years it was found that serum cholesterol levels were significantly higher in both male and female suicidal adolescent patients than in nonsuicidal adolescents.…”

Section: Introductionmentioning

confidence: 90%

Low cholesterol levels in children predict impulsivity in young adulthood

Tomson-Johanson

Kaart

Kiivet

et al. 2019

Acta Neuropsychiatr.

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AbstractObjective:Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.Methods:We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n = 1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale.Results:Total and low-density lipoprotein (LDL) cholesterol measured in boys aged 9, 15 and 18 years predicted disinhibition and thoughtlessness in 25-year-old young adults. High scores of disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes.Conclusions:Serum lipid levels could have an impact on the development of Maladaptive Impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.

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“…Three metabolic studies investigated the relationship between suicide and self-harm behaviours and cholesterol. Lower total cholesterol levels were associated with a suicide attempt history [ 137 ], and increased severity of suicidal behaviour (e.g. ideations, gestures) among those who were currently suicidal [ 138 ], while lower high density lipid cholesterol was associated with higher suicide ideation [ 139 ].…”

Section: Resultsmentioning

confidence: 99%

“… FH+: ↑ peripheral and central BP, arterial stiffness and ↓ insulin sensitivity HC: 19.1 ± 0.1 HC (27M; 42F) Suicide and self-harm [ 138 ] SUC: 15.93 ± 1.48 SUC (15M; 32F) Examine the relationship between serum cholesterol levels and suicidal behaviours Metabolic: blood serum samples SUC: ↑ cholesterol ~ current suicide behaviour (within the SUC group, ↑ serum cholesterol ~ ↓ severity of SUC, but not ~ symptom severity) PC: 16.22 ± 1.95 PC (58M; 47F) Functional: SPI PD: 25.3 ± 3.3 PD (37M; 35F) Elucidate the relationships between alexithymia, suicide ideation and serum lipid levels. Metabolic: BMI, blood serum samples PD: ↓ HDL-C and ↑ VLDL-C ~ higher suicide ideation Functional: SSI [ 137 ] SA: 15.44 ± 1.99 SA (17M; 49F) Explore the associations between cholesterol and suicidal behaviour Metabolic: blood serum samples SA: ↓ cholesterol levels ~ attempted suicide history PC: 15.19 ± 1.68 PC (15M; 39F) Functional: hospital records [ 199 ] SA: 16.8 SEM = .74 SA (3M; 6F) Investigate platelet PBR density in suicidal teens Metabolic: blood serum samples SA: ↓ platelet PBR density PC: 16.5 SEM = .5 PC (7M; 3F) Functional: hospital records, SPI, SRS [ 155 ] SA: 15.87 ± 1.56 SA(10M; 25F) Evaluate the relationship between plasma serotonin levels and psychometric measures in suicidal adolescents Metabolic: blood serum samples SA: ↓ plasma 5-HT level ~ ↑ suicidality. (5-HT did not discriminate between the psychiatric diagnostic categories) PC: 16.29 1.81 PC (19M; 11F) Functional: hospital records, SPI ER: 16.91 2.47 ER (13M; 38F) HC: 15.26 1.41 HC (45M; 50F) ...…”

Section: Methodsmentioning

confidence: 99%

The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review

et al. 2016

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BackgroundMood and anxiety disorders are leading causes of disability and mortality, due largely to their onset during adolescence and young adulthood and broader impact on functioning. Key factors that are associated with disability and these disorders in young people are social and economic participation (e.g. education, employment), physical health, suicide and self-harm behaviours, and alcohol and substance use. A better understanding of the objective markers (i.e. neurobiological parameters) associated with these factors is important for the development of effective early interventions that reduce the impact of disability and illness persistence.MethodsWe systematically reviewed the literature for neurobiological parameters (i.e. neuropsychology, neuroimaging, sleep-wake and circadian biology, neurophysiology and metabolic measures) associated with functional domains in young people (12 to 30 years) with mood and/or anxiety disorders.ResultsOf the one hundred and thirty-four studies selected, 7.6 % investigated social and economic participation, 2.1 % physical health, 15.3 % suicide and self-harm behaviours, 6.9 % alcohol and substance use, whereas the majority (68.1 %) focussed on clinical syndrome.ConclusionsDespite the predominance of studies that solely examine the clinical syndrome of young people the literature also provides evidence of distinct associations among objective measures (indexing various aspects of brain circuitry) and other functional domains. We suggest that a shift in focus towards characterising the mechanisms that underlie and/or mediate multiple functional domains will optimise personalised interventions and improve illness trajectories.

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Total serum cholesterol levels and suicide attempts in child and adolescent psychiatric inpatients

Cited by 17 publications

References 36 publications

Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies

Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies

Low cholesterol levels in children predict impulsivity in young adulthood

The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review

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