TOTAL SERUM IgE LEVELS IN CHILDREN WITH PERTUSSIS

Torre, Donato; Sampietro, Carmen; Fiori, G P; Ferraro, Giorgio; Chelazzi, G; Issi, M

doi:10.1016/s0140-6736(89)92436-7

Cited by 3 publications

(4 citation statements)

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“…In the present study, IgE serum concentrations in the children suffering from acute pertussis were in the same order of magnitude as those of the control group, even though the numerical values seemed to lie somewhat higher at first glance. Age, which played a role in the study by Torre et al [19], did not have an effect in our data. However, although we did not find an elevated serum IgE at the time of acute pertussis infection, there was a significant difference in serum IgE concentration in the children reassessed 8-14 months after pertussis compared to the control group.…”

Section: Discussioncontrasting

confidence: 50%

“…A previous clinical study has demonstrated increased levels of serum IgE in children aged 3-12 years who were acutely affected by whooping cough in the paroxysmal stage; a follow-up during the course of the disease even revealed a further and significant increment in serum IgE levels in these children 10 days later [19]. However, this did not hold true for younger children, and a longterm follow-up was not carried out.…”

Section: Discussionmentioning

confidence: 93%

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Does pertussis infection induce manifestation of allergy?

Schuster

Hofmann

Reinhardt³

1993

Clin Investig

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To evaluate whether pertussis induces the development of allergy, a prospective study was performed in 25 children aged 0.8-12.2 years. The patients underwent allergy diagnostics during pertussis infection and at a follow-up visit 8-14 months later. Diagnostic criteria included the medical history of the patients and their families, a modified skin prick test, measurement of serum IgE and radio-allergosorbent test screening for specific sensitizations. At the time of pertussis, serum IgE concentration in the study group was 62 +/- 30 kU/ml. At the follow-up visit, there was a significant increase in serum IgE to 137 +/- 51 kU/ml, which was also significantly higher than IgE in an age-matched control group. Children at a significantly higher risk for developing IgE increase or new allergic sensitizations were those with a family history of allergy or potentially allergic disease in their personal history. Our results indicate that pertussis may induce IgE production in affected children.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 93%

Does pertussis infection induce manifestation of allergy?

Schuster

Hofmann

Reinhardt³

1993

Clin Investig

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“…Previous work has shown that such antibodies were below the limit of detection and did not contribute to the elevated levels of circulating IgE in the rats [7]. A rise in total serum IgE has been reported in some children with pertussis [13] and a low incidence of B. pertussis-specific IgE antibodies has been detected [ 141.…”

Section: Resultsmentioning

confidence: 99%

Time-course of infection and responses in a coughing rat model of pertussis

Hall¹,

Parton²,

Wardlaw³

1999

Journal of Medical Microbiology

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Adult female Sprague-Dawley rats were challenged intrabronchially with BordeteZlu pertussis strain 18-323 embedded in fine agarose beads and the time-course of infection and other events was determined. There was a steady decline in the numbers of B. pertussis recovered from the rat lungs, with clearance of the infection in most animals by day 12. Leucocytosis, lung inflammation and an increase in total serum IgE in the rats as a result of the challenge were highest around day 10, which was coincident with the highest incidence of coughing in such animals. IgG and IgA antibodies to the B. pertussis antigens pertussis toxin and filamentous haemagglutinin were not detected until after this period. The coughing rat model of pertussis resembles the human disease in the relationship between the time course of infection and cough production.

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“…Hitherto, the IgE-enhancing effect of PT has only been described in vivo, both for rodents [7][8][9][10] and for humans [26,27]. So far, attempts to show in vitro IgE-enhancing activity have not been reported.…”

Section: Discussionmentioning

confidence: 99%

Co-Stimulation of T cells via CD28 inhibits human IgE production; reversal by Pertussis toxin

Pouw-Kraan¹,

Rensink²,

Rappuoli

et al. 1995

Clinical and Experimental Immunology

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SUMMARYIn lymphocyte cultures, IgE production was achieved by stimulating T cells wilh anti-CD2 and lL-2. Here we show that anti-CD28, in the presence or absence of IL-2, reduces this IgE production approximately 10-fold. This inhibition of IgE production was almost completely reversed by Pertussis toxin (PT). PT had no effect on IgE production when the cells were stimulated in the absence of anti-CD28. No major effects of PT were found on IgM production. PT had no effect on purified B cells, stimulated with IL-4 and anti-CD40. In the presence of saturating amounts of rIL-4 similar results were obtained, albeit the absolute amounts of IgE produced were higher in all situations. Furthermore, PT-induced IgE production was still dependent on IL-4, as was evident from experiments in which anti-IL-4 was added to the culture. The IgE enhancing effect was dependent on the adenosine diphosphate (ADP)-ribosyltransferase activity of PT, because a mutant molecule lacking this activity was not able to restore anti-CD28-induced inhibition of IgE synthesis. Thtis, we show that co-stimulation with anti-CD28 causes an inhibition of T cell-dependent IgE production by B cells, which inhibition can be specifically overcome by PT. An analysis of the molecular pathways underlying this phenomenon may contribute to our understanding of the regulation of IgE synthesis in {patho)physiological conditions.

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TOTAL SERUM IgE LEVELS IN CHILDREN WITH PERTUSSIS

Cited by 3 publications

References 1 publication

Does pertussis infection induce manifestation of allergy?

Does pertussis infection induce manifestation of allergy?

Time-course of infection and responses in a coughing rat model of pertussis

Co-Stimulation of T cells via CD28 inhibits human IgE production; reversal by Pertussis toxin

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