Total Skin Electron Irradiation in Mycosis fungoides

Abstract

Total skin irradiation with fast electrons (4 MeV, 3,500 rad) was applied in 10 cases of histologically proven mycosis fungoides without any signs of internal dissemination. The technique is described. Complete disappearance of both lesions and symptoms occurred in all patients after treatment. However, half of the patients relapsed after the initial irradiation and were subsequently treated with a booster dose of 1,000 rad 4 MeV electrons or with topical nitrogen mustard. Irradiation with fast electrons seems to be of great importance in the treatment of mycosis fungoides.

Cutaneous T-cell lymphoma: clinicopathological relationships, therapy and survival in ninety-two patients

“…Patients in stage I or II were treated with E beam (35 Gy, 4 MeV) (Fuks et al, 1973;Van Vloten, Vermey & De Vroome, 1977), topical HN2 (Van Scott & Kalmanson, 1973;Hamminga, Noordijk & Van Vloten, 1982) or, after 1976, PUVA (Gilchrest et al, 1976.…”

Internal dissemination of mycosis fungoides despite successful local therapy

“…On the basis of the results of all investigations the dis-Acta Dermarovener /Stockholm/ 58, /978 ease was regarded as purely cutaneous and the patient was treated with total skin electron irradiation up to 3800 rad, 4 MeV (8). A resistant tumour behind the left ear was addi tionally X-irradiated.…”

Systemic polychemotherapy in patients with mycosis fungoides and lymph node involvement: a follow-up study of 17 patients

“…Ten out ofthese 17 patients received total-skin electron beam irradiation (35 Gy, 4 MeV) (5,6) prior to the cytostatic therapy (E+COP). The selection of patients for irradiation treatment was not randomized, but was based on the general health of the patient, availability of the linear accelerator and the extent of skin involvement.…”