Total sleep deprivation and novelty processing: implications for frontal lobe functioning

Gosselin, Anik; Koninck, Joseph De; Campbell, Kenneth B.

doi:10.1016/j.clinph.2004.07.033

Cited by 93 publications

(75 citation statements)

References 58 publications

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“…Another set of data showed that after 36 hours of sleep deprivation, the application of the target stimuli resulted in a decreased amplitude of the P3 component in the frontal and apical skull regions. Applying the novelty stimuli under the same conditions brought about a decreased activity of P3 only in the prefrontal area [110]. The relocation of the cortical functions and the activation of the prefrontal regions, which was noted after sleep deprivation, may also be connected with the ability of these areas to recover within a relatively short time during the rebound sleep.…”

Section: Dermal Effectsmentioning

confidence: 90%

Consequences of sleep deprivation

Orzeł-Gryglewska¹

2010

International Journal of Occupational Medicine and Environmental Health

214

133

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This paper presents the history of research and the results of recent studies on the effects of sleep deprivation in animals and humans. Humans can bear several days of continuous sleeplessness, experiencing deterioration in wellbeing and effectiveness; however, also a shorter reduction in the sleep time may lead to deteriorated functioning. Sleeplessness accounts for impaired perception, difficulties in keeping concentration, vision disturbances, slower reactions, as well as the appearance of microepisodes of sleep during wakefulness which lead to lower capabilities and efficiency of task performance and to increased number of errors. Sleep deprivation results in poor memorizing, schematic thinking, which yields wrong decisions, and emotional disturbances such as deteriorated interpersonal responses and increased aggressiveness. The symptoms are accompanied by brain tissue hypometabolism, particularly in the thalamus, prefrontal, frontal and occipital cortex and motor speech centres. Sleep deficiency intensifies muscle tonus and coexisting tremor, speech performance becomes monotonous and unclear, and sensitivity to pain is higher. Sleeplessness also relates to the changes in the immune response and the pattern of hormonal secretion, of the growth hormone in particular. The risk of obesity, diabetes and cardiovascular disease increases. The impairment of performance which is caused by 20-25 hours of sleeplessness is comparable to that after ethanol intoxication at the level of 0.10% blood alcohol concentration. The consequences of chronic sleep reduction or a shallow sleep repeated for several days tend to accumulate and resemble the effects of acute sleep deprivation lasting several dozen hours. At work, such effects hinder proper performance of many essential tasks and in extreme situations (machine operation or vehicle driving), sleep loss may be hazardous to the worker and his/her environment.

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Section: Dermal Effectsmentioning

confidence: 90%

Consequences of sleep deprivation

Orzeł-Gryglewska¹

2010

International Journal of Occupational Medicine and Environmental Health

214

133

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“…Fragmented sleep or sleep deprivation reduces the amplitude and/or lengthens the latency of the ''frontal'' P3 (Morris et al 1992;Martin et al 1996;Kingshott et al 2000). Taken together, these data suggest impairments in executive functioning probably due to deactivation of frontal brain areas after sleep disturbance (Kaneda et al 1999;Gosselin et al 2005).…”

Section: Introductionmentioning

confidence: 89%

Executive brain functions after exposure to nocturnal traffic noise: effects of task difficulty and sleep quality

et al. 2006

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The after-effects of nocturnal traffic noise on cognitive performance and inhibitory brain activity were investigated. Twenty participants (18-30 years) performed an easy and a difficult visual Go/Nogo task with simultaneous EEG recording after a quiet night and then during three nights when aircraft noise was presented with equivalent noise levels of 39, 44, and 50 dBA, respectively, between 11 p.m. to 7 a.m. Based on subjective sleep quality rating, participants were separated into "good" versus "bad" sleepers. The performance and inhibition-related components (N2, P3) of event-related potentials were analysed. The N2 and P3 amplitudes were smaller and latencies were prolonged in the difficult than in the easy task. This effect was more pronounced for Nogo than for Go trials. The Nogo-P3 amplitude was smaller in Noise than in "Quiet" conditions in the difficult task only. In the difficult task, the Nogo-P3 latency was prolonged in bad sleepers than in good sleepers. The Nogo-P3 amplitude was reduced in Noise as compared to "Quiet" conditions in bad sleepers only. Sleep quality in bad sleepers worsened steadily with increasing noise levels. No effects of noise or subjective sleep quality on performance were found. Inhibitory processes appear to be selectively impaired after nocturnal noise exposure. The task difficulty and perceived sleep quality are important factors modulating noise effects. The results suggest that nocturnal traffic noise increase physiological costs for inhibitory functioning on the day even if no overt performance decrement is observed.

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“…Both sleep deprivation and ageing disturb brain functions (Spiegel et al 1999;Urrila et al 2004;Prinz et al 2004;Gosselin et al 2005). Sleep deprivation produces effects similar to those that occur in the course of ageing.…”

Section: Introductionmentioning

confidence: 93%

Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats

et al. 2008

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The present study examined the effects of paradoxical sleep (PS) deprivation on the oxidative stress parameters: lipid peroxidation, superoxide dismutase, glutathione peroxidase, and glutathione in brain regions: cerebral cortex, striatum, hippocampus, thalamus, hypothalamus, and brain stem of adult (8 months) and old (24 months) rats. PS deprivation (96 h) was performed by the classical flower pot technique. PS deprivation did not affect oxidative stress parameters in the striatum of both age groups; and the activity of glutathione peroxidase was not affected in any of the studied brain regions in both age groups. PS deprivation decreased the levels of glutathione only in the hippocampus, thalamus and hypothalamus; the magnitude of decrease was higher in the old than in the adult age group. PS deprivation increased the superoxide dismutase activity in the cerebral cortex and brain stem but reduced it in the hippocampus, thalamus and hypothalamus in both age groups. Increases in the activity were greater in adult animals than in old ones; the decline in the activity was greater in the hippocampus of old animals than in that of the adult ones. Lipid peroxidation was reduced by PS deprivation in the cerebral cortex and brain stem but was elevated in the hypothalamus and thalamus: the magnitude of alteration in the cerebral cortex, brain stem, hippocampus and hypothalamus was higher in adult animals than in old ones. The results showed that oxidative stress was not uniformly affected in all the brain regions. The cerebral cortex and brain stem showed a fall in oxidative stress after PS deprivation; the fall was greater in the adult than in the old animals. However, the oxidative stress was elevated in the hippocampus, thalamus and hypothalamus, and old animals were more severely affected than the adult ones.

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Total sleep deprivation and novelty processing: implications for frontal lobe functioning

Cited by 93 publications

References 58 publications

Consequences of sleep deprivation

Consequences of sleep deprivation

Executive brain functions after exposure to nocturnal traffic noise: effects of task difficulty and sleep quality

Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats

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