Total Syntheses of Liphagal: A Potent and Selective Phosphoinositide 3-Kinase α (PI3Kα) Inhibitor from the Marine Sponge Aka coralliphaga

Abstract

-Liphagal, isolated from the marine sponge Aka coralliphaga, exhibits a potent and selective inhibitory activity against phosphoinositide 3-kinase α (PI3Kα). This marine natural product has attracted significant attention because of its potential as a promising candidate or new lead for the development of novel molecular targeted anticancer agents. In this review, the reported total syntheses of liphagal are presented with a particular focus on the methodologies and strategies employed.