Total Synthesis, Discovery and Biological Evaluation of Daldinin A Derivatives for Improving Hyperglycemia-Induced Endothelial Cell Death

Abstract

Daldinins are a novel type of naturally occurring tricyclic heterocycles isolated from Daldinia concentrica. In this study, four daldinin A derivatives with different alkyl side chains were synthesized using the same synthetic protocol. Bioactivity tests first indicated that the daldinin A derivatives showed significant protection for endothelial cells against damage caused by high glucose. The derivative compound with three carbon atoms on the alkyl side exhibited the best effect.

Construction of an Angular Tricyclic Benzofuran Skeleton Using the C–H Activation Strategy

“…The construction of skeletons of natural products, followed by the total synthesis of many natural products based on the skeleton via a single synthetic method, is of great significance in organic chemistry. In a previous study, we achieved the total synthesis of angular tricyclic benzofurans, a type of secondary metabolite from different species with high fungal metabolism and potential bioactivities, − based on a common synthetic method.…”