Total Synthesis of (±)‐20‐epi‐Kopsiyunnanine K: A Domino and Stereocontrolled Approach

Abstract

A one‐pot route to a novel azepane‐fused tetrahydro‐β‐carboline framework from tryptyl‐4‐pentenamide derivatives has been developed, featuring the Rh‐catalyzed hydroformylation double cyclization. Subsequent alkylation in the tetracyclic system proceeded stereoselectively to form a quaternary carbon. The synthesis of (±)‐20‐epi‐kopsiyunnanine K was accomplished through the strategy.