Total Synthesis of 3′,3′′′-Binaringenin and Related Biflavonoids

Abstract

The synthesis of natural 3¢,3¢¢¢-binaringenin and four related biflavonoids was performed in good overall yield (15-35%) starting from readily available phloroglucinol and 4-hydroxy-or 4-methoxybenzaldehyde. Preliminary results indicate that some of these compounds have an interesting activity against S. aureus.