Total synthesis of bistramide D

Abstract

Introduction to bistramides 1.2 Recent synthetic studies of bistramides 1.3 Conclustion CHAPTER 2: SYNTHESIS OF THE THP FRAGMENT OF BISTRAMIDE D 2.1 Retrosynthetic approach to THP unit 2.2 Background: introduction to the previous studies 2.3 New studies on the synthesis of natural THP ring of bistramide D 2.4 Conclusion 68 CHAPTER 3: REVIEW ON STRATEGIES FOR SPIROKETAL SYNTHESIS 3.1 Scope of the review 3.2 Introduction to spiroketals 3.3 General methods for the synthesis of spiroketals 3.4 Conclustion 4 CHAPTER 4: SYNTHESIS OF THE SPIROKETAL FRAGMENT OF BISTRAMIDE D 4.1 Introduction 118 4.2 Preliminary study of the spiroketal fragment 119 4.3 Synthesis of the natural spiroketal fragment of bistramide D 141 4.4 Conclusion 163 4.5 Future work