Total synthesis of both enantiomers of the biosurfactant aureosurfactin via bidirectional synthesis with a chiral Horner–Wittig building block

Abstract

The first de novo synthesis of (−)- and (+)-aureosurfactin, using a chiral Horner–Wittig building block. Both enantiomers of the biosurfactant are easily accessible starting from only one chiral pool via a bidirectional synthetic strategy.