Total Synthesis of Cladosins B and C

Reber, Keith P.; Mease, James; Kim, Justin

doi:10.1021/acs.joc.0c01605

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Marine Microorganisms and Phytoplankton1

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2021

2023

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Cited by 3 publications

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“…287 Known terrestrial flavone chrysin 796 was isolated from Chaetomium globosum as a new MNP. 288 Completed total syntheses of fungal metabolites included those of wickerol B, 289 (+)-penostatin A and (+)-penostatin C, 290 versicotides A–C, 291 cladosin B, 292 spirograterpene A, 293 nafuredin B, 294 chondristerins I and J, 295 aspergillusene B 296 and yicathins B and C. 297…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2022

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Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2022

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Antiviral fungal metabolites and some insights into their contribution to the current COVID-19 pandemic

Takahashi

Barbosa

Lima

et al. 2021

Bioorganic & Medicinal Chemistry

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, which started in late 2019 drove the scientific community to conduct innovative research to contain the spread of the pandemic and to care for those already affected. Since then, the search for new drugs that are effective against the virus has been strengthened. Featuring a relatively low cost of production under well-defined methods of cultivation, fungi have been providing a diversity of antiviral metabolites with unprecedented chemical structures. In this review, we present viral RNA infections highlighting SARS-CoV-2 morphogenesis and the infectious cycle, the targets of known antiviral drugs, and current developments in this area such as drug repurposing. We also explored the metabolic adaptability of fungi during fermentation to produce metabolites active against RNA viruses, along with their chemical structures, and mechanisms of action. Finally, the state of the art of research on SARS-CoV-2 inhibitors of fungal origin is reported, highlighting the metabolites selected by docking studies.

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