Total Synthesis of (+)‐Isatisine A

Total Synthesis of (+)-Isatisine A

“…Recently, the first total synthesis, achieved by Kerr and co-worker, revealed that the assignment of absolute configuration originally provided by Chen’s group is antipodal to the natural product. 2 …”

Total Synthesis of (−)‐Isatisine A

“…Extensive NMR spectroscopic analyses and X‐ray crystallographic analysis of 2 revealed that isatisine A ( 1 ) features an unprecedented fused tetracyclic framework with five contiguous stereogenic centers, two of which are fully substituted, and a densely functionalized tetrahydrofuran core. The absolute configuration of these two bisindole alkaloids was established by the first total synthesis of (+)‐isatisine A ( ent ‐ 1 ), which was reported by Karadeolian and Kerr (Scheme ),3 and later was confirmed by the total synthesis of ent ‐ 1 by Lee and Panek (Scheme ) 4…”

Rhodium(III)‐Catalyzed Annulation of 2‐Alkenyl Anilides with Alkynes through C−H Activation: Direct Access to 2‐Substituted Indolines

“…[15] There are many natural structures with 3-oxoindoline skeletons (see some examples in Scheme 1), and our methodology promises to provide ar apid entry to compounds of this type. [15] There are many natural structures with 3-oxoindoline skeletons (see some examples in Scheme 1), and our methodology promises to provide ar apid entry to compounds of this type.…”

“…Zuschriften and 3ai could be readily converted into the corresponding 3oxoindolines by selective oxidation of the exomethylene group (Scheme 4). [15] There are many natural structures with 3-oxoindoline skeletons (see some examples in Scheme 1), and our methodology promises to provide ar apid entry to compounds of this type.…”