Total Synthesis of Marine Macrolide Natural Products by the Macrocyclization/Transannular Pyran Cyclization Strategy

Abstract

In this Account, we summarize the development of a new strategy for streamlined synthesis of tetrahydropyran-embedded macrolactones and its successful implementation to a 13-step synthesis of (−)-exiguolide and an 11-step synthesis of (+)-neopeltolide. 1 Introduction 2 Development of Macrocyclization/Transannular Pyran Cyclization Strategy 3 Total Synthesis of (–)-Exiguolide 4 Total Synthesis of (+)-Neopeltolide 5 Conclusions