Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

Abstract

Described is a total synthesis of racemic mersicarpine from diethyl 4-oxopimelate. The synthetic route takes advantage of a 2-indolyl radical cyclization to construct the pyrido[1,2-a]indole scaffold bearing the all-carbon quaternary...

A Copper-Mediated Radical α-Heteroarylation of Nitriles with Azobis(alkylcarbonitriles)

“…Our laboratory is currently investigating the potential of this promising intramolecular cyclization reaction to synthesize valuable scaffolds for Aspidosperma alkaloids. 19 …”