Total Synthesis of Taiwaniaquinoids: A Strategic Account

Abstract

Due to their novel architectures and promising biological activities, the family of taiwaniaquinoid natural products continues to capture the attention of synthetic chemists. This mini‐review highlights recent advances in the total synthesis of taiwaniaquinoids, with a focus on the overarching synthetic strategies that have been employed to access the structural and stereochemical diversity that exists among these plant secondary metabolites.

A regioselective [3 + 2] cycloaddition reaction of 2-benzylidene-1-indenones with functional olefins to access indanone-fused 2D/3D skeletons

“…1 Thus, the synthesis of these interesting molecules has attracted a sustained amount of attention from chemists. 2 However, most synthesized indanone-fused polycyclic molecules are restricted to indanone-based two-dimensional (2D) aromatic rings, for example (hetero)fluorenes. 3 Meanwhile, the catalytic synthesis of (hetero)fluorenes has been rapidly developed, and many powerful and innovative methodologies have been established to construct these molecules.…”