Total Synthesis of the Bis-silyl Ether of (+)-15-<i>epi</i>-Aetheramide A

Revu, Omkar; Prasad, Kavirayani R.

doi:10.1021/acs.joc.6b02535

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…Remarkably, once again, the presence of unprotected functionalities was well tolerated under these ruthenium-catalyzed reaction conditions, thus underscoring the mildness and efficiency of these reactions in a complex setting. From (He, 2017) [74] O [75] (49%)…”

Section: Syn Thesismentioning

confidence: 99%

Recent Advances in Total Synthesis via Metathesis Reactions

Cheng-Sánchez

Sarabia

2018

Synthesis

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The metathesis reactions, in their various versions, have become a powerful and extremely valuable tool for the formation of carbon–carbon bonds in organic synthesis. The plethora of available catalysts to perform these reactions, combined with the various transformations that can be accomplished, have positioned the metathesis processes as one of the most important reactions of this century. In this review, we highlight the most relevant synthetic contributions published between 2012 and early 2018 in the field of total synthesis, reflecting the state of the art of this chemistry and demonstrating the significant synthetic potential of these methodologies.1 Introduction2 Alkene Metathesis in Total Synthesis2.1 Total Synthesis Based on a Ring-Closing-Metathesis Reaction2.2 Total Synthesis Based on a Cross-Metathesis Reaction2.3 Strategies for Selective and Efficient Metathesis Reactions of Alkenes2.3.1 Temporary Tethered Ring-Closing Metathesis2.3.2 Relay Ring-Closing Metathesis2.3.3 Stereoselective Alkene Metathesis2.3.4 Alkene Metathesis in Tandem Reactions3 Enyne Metathesis in Total Synthesis3.1 Total Syntheses Based on a Ring-Closing Enyne-Metathesis Reaction3.2 Total Syntheses Based on an Enyne Cross-Metathesis Reaction3.3 Enyne Metathesis in Tandem Reactions4 Alkyne Metathesis in Total Synthesis4.1 Total Synthesis Based on a Ring-Closing Alkyne-Metathesis Reaction4.2 Other Types of Alkyne-Metathesis Reactions5 Conclusions

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Section: Syn Thesismentioning

confidence: 99%

Recent Advances in Total Synthesis via Metathesis Reactions

Cheng-Sánchez

Sarabia

2018

Synthesis

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“…Still, in 2016 He et al reported the preparation of aetheramides A and B by using a different strategy (15 steps, 4.7 % overall yield) . Three different approaches were also tested in the synthesis of the protected aetheramide by Revu and Prasad in 2017 . The total synthesis of aetheramide A was also accomplished by Kalesse et al in 2016 (18 steps, 0.24 % overall yield).…”

Section: Introductionmentioning

confidence: 99%

“…[7] Three different approaches were also tested in the synthesis of the protected aetheramide by Revu and Prasad in 2017. [8] The total vanced chiral building blocks: (R,R)-and (R,S)-vinylboronates and an (R)-iodoalkene. The former was prepared from (R)mandelic acid, and the latter was prepared by enantioselective allylation of 3-iodoacrylaldehyde.…”

Section: Introductionmentioning

confidence: 99%

Enantioselective Synthesis of the C23–C33 Fragment of Aetheramide A and Its C32 Epimer

Koukal

Kotora

2017

Eur J Org Chem

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“…Recently, Liu finished the synthesis of nannocystin Ax. Continuing our interest in natural products with medicinal potential, we pursued the total synthesis of nannocystin A, and successfully developed a concise and efficient asymmetric synthetic strategy.…”

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confidence: 99%